@misc{oai:kumadai.repo.nii.ac.jp:00027832,
 author = {マームド ホセイン and Mahmud Hossain},
 month = {Sep},
 note = {application/pdf, 学位論文(Thesis), Background and Purpose: Previously we reported the identification of two secreted
proteins: draxin and Tsukushi (TSK). Draxin knockout mice showed agenesis of all
forebrain commissures: corpus callosum (CC), hippocampal commissure (HC), and
anterior commissure (AC). Moreover, genetic deletion of TSK in mice also results in
the agenesis of AC and CC, also suggesting the importance of TSK function in
forebrain commissure formation. As both draxin and TSK single mutant mice
converge into common phenotypes, there is a possibility that the combined function
of these two proteins is essential for the formation of forebrain commissures.
Furthermore, we documented that draxin exerts its chemorepulsive function through
netrin’s chemoattractive receptor, DCC. As different ligands interacted with the same
receptor, DCC and shows opposite functions of axon guidance, there might be some
other molecule(s) that also interact with DCC to perform the opposite signaling
pathway. Additionally, we also tried to explore the function of draxin after brain
injury.},
 title = {Study of draxin and Tsukushi function in brain development and injury},
 year = {2012}
}