@article{oai:kumadai.repo.nii.ac.jp:00027975,
 author = {小西, 正紹 and Konishi, Masaaki and 杉山, 正悟 and 菅村, 公一 and Sugamura, Koichi and 野崎, 俊光 and Nozaki, Toshimitsu and 松原, 純一 and Matsubara, Junichi and 秋山, 英一 and Akiyama, Eichi and 宇都宮, 大輔 and 松澤, 泰志 and Matsuzawa, Yasushi and 山下, 康行 and 木村, 和生 and Kimura, Kazuo and 梅村, 敏 and Umemura, Satoshi and Ogawa, Hisao and 小川, 久雄 and 小西, 正紹 and Konishi, Masaaki and 杉山, 正悟 and Sugiyama, Seigo and 菅村, 公一 and Sugamura, Koichi and 野崎, 俊光 and Nozaki, Toshimitsu and 松原, 純一 and Matsubara, Junichi and 秋山, 英一 and Akiyama, Eichi and 宇都宮, 大輔 and Utsunomiya, Daisuke and 松澤, 泰志 and Matsuzawa, Yasushi and 山下, 康行 and Yamashita, Yasuyuki and 木村, 和生 and Kimura, Kazuo and 梅村, 敏 and Umemura, Satoshi and Ogawa, Hisao and 小川, 久雄},
 issue = {3},
 journal = {Journal of Cardiology},
 month = {May},
 note = {application/pdf, application/pdf, application/pdf, 論文(Article), Background Left ventricular diastolic dysfunction (LVDD) plays an important role in
heart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of
the major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot
with possible paracrine or mechanical effects on the coronary circulation and
35 myocardial function.
Methods We measured PF volume on 64 slice computed tomography and analyzed
echocardiographic parameters to confirm LVDD in 229 consecutive patients suspected
of coronary artery disease with LVEF of more than 50% and no symptomatic heart
failure (59% men, 67±12 years). LVDD was defined as the ratio of transmitral
40 Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity
(E/e’) >10.
Results PF volume correlated significantly with E/e’ (r=0.21, p<0.01), left ventricular
mass index (r=0.23, p<0.001), and left atrial diameter (r=0.32, p<0.001). The mean PF
volume was significantly greater in patients with LVDD (184±61 cm3, n=141) than in
45 those without LVDD (154±58, n=88, p<0.001). Multivariate logistic regression
analysis indicated that PF volume correlated significantly with the presence of LVDD
(odds ratio: 2.00 per 100 cm3 increase in PF volume, p=0.02) independent of age,
gender, abdominal obesity, hypertension, and diabetes.
Conclusions PF volumes are significantly associated with LVDD, independent of
50 other factors such as hypertension or diabetes. PF may be implicated in the pathogenesis of LVDD in patients with normal LVEF., http://www.journal-of-cardiology.com/article/S0914-5087%2812%2900010-X/abstract@@@http://www.sciencedirect.com/science/article/pii/S091450871200010X},
 pages = {344--351},
 title = {Accumulation of Pericardial Fat Correlates with Left Ventricular Diastolic Dysfunction in Patients with Normal Ejection Fraction},
 volume = {59},
 year = {2012},
 yomi = {コニシ, マサアキ and スガムラ, コウイチ and ノザキ, トシミツ and マツバラ, ジュンイチ and アキヤマ, エイイチ and マツザワ, ヤスシ and キムラ, カズオ and ウメムラ, サトシ and オガワ, ヒサオ and コニシ, マサアキ and スギヤマ, セイゴ and スガムラ, コウイチ and ノザキ, トシミツ and マツバラ, ジュンイチ and アキヤマ, エイイチ and ウツノミヤ, ダイスケ and マツザワ, ヤスシ and ヤマシタ, ヤスユキ and キムラ, カズオ and ウメムラ, サトシ and オガワ, ヒサオ}
}