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diastolic dysfunction (LVDD) plays an important role in\nheart failure with normal left ventricular ejection fraction (LVEF). Obesity is one of\nthe major comorbid conditions of LVDD. Pericardial fat (PF) is an ectopic fat depot\nwith possible paracrine or mechanical effects on the coronary circulation and\n35 myocardial function.\nMethods We measured PF volume on 64 slice computed tomography and analyzed\nechocardiographic parameters to confirm LVDD in 229 consecutive patients suspected\nof coronary artery disease with LVEF of more than 50% and no symptomatic heart\nfailure (59% men, 67±12 years). LVDD was defined as the ratio of transmitral\n40 Doppler early filling velocity to tissue Doppler early diastolic mitral annular velocity\n(E/e’) >10.\nResults PF volume correlated significantly with E/e’ (r=0.21, p<0.01), left ventricular\nmass index (r=0.23, p<0.001), and left atrial diameter (r=0.32, p<0.001). The mean PF\nvolume was significantly greater in patients with LVDD (184±61 cm3, n=141) than in\n45 those without LVDD (154±58, n=88, p<0.001). Multivariate logistic regression\nanalysis indicated that PF volume correlated significantly with the presence of LVDD\n(odds ratio: 2.00 per 100 cm3 increase in PF volume, p=0.02) independent of age,\ngender, abdominal obesity, hypertension, and diabetes.\nConclusions PF volumes are significantly associated with LVDD, independent of\n50 other factors such as hypertension or diabetes. PF may be implicated in the pathogenesis of LVDD in patients with normal LVEF.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.journal-of-cardiology.com/article/S0914-5087%2812%2900010-X/abstract@@@http://www.sciencedirect.com/science/article/pii/S091450871200010X","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese College of 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