{"created":"2023-06-19T09:15:46.389968+00:00","id":28171,"links":{},"metadata":{"_buckets":{"deposit":"0541e16c-2c48-4268-8c62-08c01736e99a"},"_deposit":{"created_by":1,"id":"28171","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"28171"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00028171","sets":["413:443"]},"author_link":["128350","128345","128367","126547","128369","128347","128371","128377","128351","128368","128376","128342","128352","128346","128372","128374","128370","128366","128373","128349","128348","128375","128343"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"807","bibliographicPageStart":"801","bibliographicVolumeNumber":"421","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"末藤, 美星"}],"nameIdentifiers":[{"nameIdentifier":"128366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川, 昇"}],"nameIdentifiers":[{"nameIdentifier":"128367","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松本, 和也","creatorNameLang":"ja"},{"creatorName":"マツモト, カズヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Kazuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"松本","familyNameLang":"ja"},{"familyName":"マツモト","familyNameLang":"ja-Kana"},{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"和也","givenNameLang":"ja"},{"givenName":"カズヤ","givenNameLang":"ja-Kana"},{"givenName":"Kazuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"128368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大礒, 洋"}],"nameIdentifiers":[{"nameIdentifier":"128369","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"下田, 誠也"}],"nameIdentifiers":[{"nameIdentifier":"128370","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉永, 智昭"}],"nameIdentifiers":[{"nameIdentifier":"128371","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松山, 利奈"}],"nameIdentifiers":[{"nameIdentifier":"128372","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮川, 克俊"}],"nameIdentifiers":[{"nameIdentifier":"128373","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"近藤, 龍也"}],"nameIdentifiers":[{"nameIdentifier":"128374","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河島, 淳司"}],"nameIdentifiers":[{"nameIdentifier":"128375","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水流添, 覚"}],"nameIdentifiers":[{"nameIdentifier":"128376","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒木, 栄一"}],"nameIdentifiers":[{"nameIdentifier":"128377","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Ca2+/calmodulin-dependent protein kinase II (CaMKII) is expressed in insulin-secreting\nβ cells. However, the effects of CaMKII on insulin synthesis are unknown. Although\nSer133 phosphorylation of cyclic AMP-responsive element-binding (CREB) typically\nincreases CREB transcriptional activity, CaMKII phosphorylates CREB at Ser142 and\nat Ser133 to exert a dominant inhibitory effect. Our objective was to characterize the\nrole of CaMKII in insulin gene expression. In MIN6 cells, insulin gene promoter\nactivity was significantly down-regulated by wild-type (WT) CaMKIIδ2, but was\nsignificantly upregulated after small interfering RNA (siRNA) knockdown of CaMKIIδ\nexpression. These results were independent of glucose concentrations and membrane\ndepolarization. Insulin mRNA levels were also decreased by WT CaMKIIδ2 and\nincreased by CaMKIIδ siRNA. Downregulation of insulin gene promoter activity by\nWT CaMKIIδ2 was partly mediated via cyclic AMP-responsive element 2. WT\nCaMKIIδ2 significantly increased CREB phosphorylation at Ser142 and significantly decreased binding to CREB binding protein (CBP), whereas kinase dead CaMKIIδ2 did\nnot. Our results indicate that CaMKIIδ2 downregulates insulin gene expression by\nSer142 phosphorylation of CREB and reducing binding of CREB to CBP.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/article/pii/S0006291X12007735","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_16_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"22554507","subitem_relation_type_select":"PMID"}}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2012.04.091","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"@Elsevier"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006291X","subitem_source_identifier_type":"ISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"122731 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promoter","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The impact of Ca2+/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The impact of Ca2+/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-03-06"},"publish_date":"2014-03-06","publish_status":"0","recid":"28171","relation_version_is_last":true,"title":["The impact of Ca2+/calmodulin-dependent protein kinase II on insulin gene expression in MIN6 cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-07T01:26:23.212124+00:00"}