{"created":"2023-06-19T09:16:21.586164+00:00","id":28793,"links":{},"metadata":{"_buckets":{"deposit":"c28bc55f-cf78-42a9-b4fd-0e14612587a3"},"_deposit":{"created_by":1,"id":"28793","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"28793"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00028793","sets":["415:416"]},"author_link":["132070","132071","132069"],"item_16_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study on Molecular Function of Proteins of Human Immunodeficiency Virus"}]},"item_16_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"エイズ ウイルス タンパクシツ ノ ブンシ キノウ ニ カンスル ケンキュウ"}]},"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1111","bibliographicPageStart":"1103","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"藥學雑誌"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fujita, Mikako"}],"nameIdentifiers":[{"nameIdentifier":"132071","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Human immunodeficiency virus (HIV) has no more than nine genes expressing approximately twenty proteins. When T lymphocytes and macrophages in a body are infected with HIV, these proteins work in turn at specific time and location, causing acquired immunodeficiency syndrome (AIDS), a disease yet to be overcome. Since the elucidation of molecular mechanism of HIV proteins should lead to remedy of AIDS, the author has been engaged in the study of HIV protein in the past decade. Described herein are viral protein X (Vpx), uniquely found in HIV-2,and its homologous protein Vpr found both in HIV-1 and -2. We found that Vpx enhances genome nuclear import in T lymphocytes, and is critical for reverse transcription of viral RNA in macrophages. This finding on the function in macrophages corrected long-term misleading belief. Furthermore, functional region mapping of Vpx was performed. In 2011, the protein SAMHD1 was identified as the host restriction factor counteracted by Vpx, by foreign researchers. After that, our independent study demonstrated the presence of SAMHD1-independent functions of Vpx in T cells, in addition to its SAMHD1-dependent functions in macrophages. Another topic of this review is Gag protein. Recently, it has reported by oversea researchers that PI(4,5)P2(one of phosphoinositide) regulates Pr55^<Gag> localization and assembly. In this study, we determined the binding affinity between N-terminal MA domain of Pr55^<Gag> and various phosphoinositide derivatives using surface plasmon resonance. The results suggested that both negatively charged inositol phosphates and hydrophobic acyl chain are required for the MA binding.","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/yakushi.13-00200","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2013 The Pharmaceutical Society of Japan"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00316903","subitem_source_identifier_type":"ISSN"}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"556397 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤田, 美歌子"}],"nameIdentifiers":[{"nameIdentifier":"132069","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-03"}],"displaytype":"detail","filename":"0031-6903v133_1103-1111.pdf","filesize":[{"value":"556.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"0031-6903v133_1103-1111.pdf","url":"https://kumadai.repo.nii.ac.jp/record/28793/files/0031-6903v133_1103-1111.pdf"},"version_id":"737f5222-7027-4e30-a657-9c7462d36e5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"human immunodeficiency virus","subitem_subject_scheme":"Other"},{"subitem_subject":"viral protein X (Vpx)","subitem_subject_scheme":"Other"},{"subitem_subject":"Gag","subitem_subject_scheme":"Other"},{"subitem_subject":"acquired immunodeficiency syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"SAMHD1","subitem_subject_scheme":"Other"},{"subitem_subject":"PI (4,5) P2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"エイズウイルスタンパク質の分子機能に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"エイズウイルスタンパク質の分子機能に関する研究"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-01-23"},"publish_date":"2015-01-23","publish_status":"0","recid":"28793","relation_version_is_last":true,"title":["エイズウイルスタンパク質の分子機能に関する研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T17:32:18.170072+00:00"}