{"created":"2023-06-19T09:16:39.648314+00:00","id":29197,"links":{},"metadata":{"_buckets":{"deposit":"543c8b0d-de7f-4c89-9a25-729bca49bd9f"},"_deposit":{"created_by":1,"id":"29197","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"29197"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00029197","sets":["413:443"]},"author_link":["134277","134279","134278"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"278","bibliographicPageStart":"271","bibliographicVolumeNumber":"3","bibliographic_titles":[{"bibliographic_title":"Clinical Journal of Gastroenterology"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 裕"}],"nameIdentifiers":[{"nameIdentifier":"134279","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Hepatocellular carcinoma (HCC) accounts for 85–90% of liver cancers and is one of the most frequent carcinomas in the world. HCCs classically develop against the background of chronic liver diseases. Common causes of such liver diseases are viral hepatitis, alcoholic hepatitis, or immune-related diseases. However, 15–50% of patients with HCCs have none of these classic antecedents, especially in developed countries. In this context, obesity and diabetes mellitus have been found to exhibit an increased risk of HCC. Both conditions are associated with insulin resistance. The tumorigenic effects of insulin resistance and complementary hyperinsulinemia could be mediated directly by insulin signaling, or indirectly related to changes in endogeneous hormone metabolism, particularly IGF-1 (insulin-like growth factor I). Conversely, insulin resistance may be a consequence of obesity and hepatic inflammation, both of which can themselves promote tumorigenesis, mainly through cytokine production and/or generation of oxidative stress. Because the prevalence of obesity is now increasing throughout the world, insulin resistance is sure to be put more forth as a central factor for hepatocarcinogenesis in the foreseeable future.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://link.springer.com/article/10.1007%2Fs12328-010-0177-6","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Japan"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s12328-010-0177-6","subitem_relation_type_select":"DOI"}}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"18657257","subitem_source_identifier_type":"ISSN"}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12646624","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.47","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"230558 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"The final publication is available at Springer via http://dx.doi.org/10.1007/s12328-010-0177-6."},{"subitem_text_value":"【著者所属】大学院生命科学研究部(臨床系)　消化器内科学"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"134277","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-03"}],"displaytype":"detail","filename":"CJG_3(6)_271-278.pdf","filesize":[{"value":"230.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"CJG_3(6)_271-278.pdf","url":"https://kumadai.repo.nii.ac.jp/record/29197/files/CJG_3(6)_271-278.pdf"},"version_id":"8cd84152-7ffd-4763-83b3-ced594026e7f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"insulin resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"obesity","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin","subitem_subject_scheme":"Other"},{"subitem_subject":"IGF-1","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_scheme":"Other"},{"subitem_subject":"HCC","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Insulin Resistance and Hepatocarcinogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Insulin Resistance and Hepatocarcinogenesis"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-17"},"publish_date":"2015-09-17","publish_status":"0","recid":"29197","relation_version_is_last":true,"title":["Insulin Resistance and Hepatocarcinogenesis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T17:24:43.972875+00:00"}