@article{oai:kumadai.repo.nii.ac.jp:00029670,
 author = {近藤, 龍也 and 後藤, 理英子 and 小野, 薫 and 北野, さやか and 佐藤, 美希 and 井形, 元維 and 河島, 淳司 and 本島, 寛之 and 松村, 剛 and 甲斐, 広文 and 荒木, 栄一 and Kondo, Tatsuya and Goto, Rieko and Ono, Kaoru and Kitano, Sayaka and Ann Suico, Mary and Sato, Miki and Igata, Motoyuki and Kawashima, Jyunji and Motoshima, Hiroyuki and Matsumura, Takeshi and Kai, Hirofumi and 荒木, 栄一 and Araki, Eiichi},
 journal = {Scientific Reports},
 month = {Oct},
 note = {application/pdf, 論文, Activation of heat shock response (HSR) improves accumulated visceral adiposity and metabolic
abnormalities in type 2 diabetes. To identify the optimal intervention strategy of the activation of the
HSR provided by mild electrical stimulation (MES) with heat shock (HS) in type 2 diabetes. This study
was a prospective, frequency-escalating, randomized, open-label, triple-arm trial in Japan. A total of
60 obese type 2 diabetes patients were randomized into three groups receiving two, four, or seven
treatments per week for 12 weeks. No adverse events were identified. MES + HS treatment (when
all three groups were combined), significantly improved visceral adiposity, glycemic control, insulin
resistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to
baseline. The reduction in HbA1c was significantly greater among those treated four times per week
(−0.36%) or seven times per week (−0.65%) than among those treated two times per week (−0.10%).
The relative HbA1c levels in seven times per week group was significantly decreased when adjusted by
two times per week group (−0.55%. p = 0.001). This research provides the positive impact of MES + HS
to treat obese patients with type 2 diabetes mellitus., http://www.nature.com/articles/srep35690},
 pages = {1--11},
 title = {Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial},
 year = {2016},
 yomi = {アラキ, エイイチ}
}