{"created":"2023-06-19T09:17:04.655157+00:00","id":29670,"links":{},"metadata":{"_buckets":{"deposit":"4bfb0b51-523d-41ae-ad00-2d260ec7f039"},"_deposit":{"created_by":1,"id":"29670","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"29670"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00029670","sets":["413:443"]},"author_link":["136188","136189","136186","136210","136211","136212","126547","136192","136184","136194","136207","136209","136214","136190","136217","136185","136187","136213","136193","136208","136216","136215","136191"],"item_24_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"肥満2型糖尿病患者に対する熱ショック応答経路活性化 : 前向き介入頻度別ランダム化3群試験"}]},"item_24_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒマン 2ガタ トウニョウビョウ カンジャ ニ タイスル ネツ ショック オウトウ ケイロ カッセイカ : マエムキ カイニュウ ヒンド ベツ ランダム カ 3グン シケン"}]},"item_24_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-10-19","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_24_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 龍也"}],"nameIdentifiers":[{"nameIdentifier":"136207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"後藤, 理英子"}],"nameIdentifiers":[{"nameIdentifier":"136208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小野, 薫"}],"nameIdentifiers":[{"nameIdentifier":"136209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北野, さやか"}],"nameIdentifiers":[{"nameIdentifier":"136210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 美希"}],"nameIdentifiers":[{"nameIdentifier":"136211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井形, 元維"}],"nameIdentifiers":[{"nameIdentifier":"136212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河島, 淳司"}],"nameIdentifiers":[{"nameIdentifier":"136213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本島, 寛之"}],"nameIdentifiers":[{"nameIdentifier":"136214","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松村, 剛"}],"nameIdentifiers":[{"nameIdentifier":"136215","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"甲斐, 広文"}],"nameIdentifiers":[{"nameIdentifier":"136216","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒木, 栄一"}],"nameIdentifiers":[{"nameIdentifier":"136217","nameIdentifierScheme":"WEKO"}]}]},"item_24_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf"}]},"item_24_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文"}]},"item_24_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Activation of heat shock response (HSR) improves accumulated visceral adiposity and metabolic\nabnormalities in type 2 diabetes. To identify the optimal intervention strategy of the activation of the\nHSR provided by mild electrical stimulation (MES) with heat shock (HS) in type 2 diabetes. This study\nwas a prospective, frequency-escalating, randomized, open-label, triple-arm trial in Japan. A total of\n60 obese type 2 diabetes patients were randomized into three groups receiving two, four, or seven\ntreatments per week for 12 weeks. No adverse events were identified. MES + HS treatment (when\nall three groups were combined), significantly improved visceral adiposity, glycemic control, insulin\nresistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to\nbaseline. The reduction in HbA1c was significantly greater among those treated four times per week\n(−0.36%) or seven times per week (−0.65%) than among those treated two times per week (−0.10%).\nThe relative HbA1c levels in seven times per week group was significantly decreased when adjusted by\ntwo times per week group (−0.55%. p = 0.001). This research provides the positive impact of MES + HS\nto treat obese patients with type 2 diabetes mellitus.","subitem_description_type":"Other"}]},"item_24_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.nature.com/articles/srep35690"}]},"item_24_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_24_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep35690","subitem_relation_type_select":"DOI"}}]},"item_24_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2016 Macmillan Publishers Limited, part of Springer Nature."}]},"item_24_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.123","subitem_subject_scheme":"NDC"}]},"item_24_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"689706 bytes"}]},"item_24_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_24_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Article"}]},"item_24_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_24_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_24_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kondo, 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Eiichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"荒木","familyNameLang":"ja"},{"familyName":"アラキ","familyNameLang":"ja-Kana"},{"familyName":"Araki","familyNameLang":"en"}],"givenNames":[{"givenName":"栄一","givenNameLang":"ja"},{"givenName":"エイイチ","givenNameLang":"ja-Kana"},{"givenName":"Eiichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"126547","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-03"}],"displaytype":"detail","filename":"srep35690.pdf","filesize":[{"value":"689.7 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