{"created":"2023-06-19T09:17:32.179854+00:00","id":30235,"links":{},"metadata":{"_buckets":{"deposit":"26502237-75d1-497c-b461-8348a34011ab"},"_deposit":{"created_by":1,"id":"30235","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"30235"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00030235","sets":["343:347:348:349"]},"author_link":["140154"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"プレセニリン-2遺伝子における新たなイントロン多型とアルツハイマー病の患者-対象調査について"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"プレセニリン 2 イデンシ ニ オケル アラタ ナ イントロン タケイ ト アルツハイマービョウ ノ カンジャ タイショウ チョウサ ニ ツイテ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"585","bibliographicPageStart":"579","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Psychiatry and Clinical Neurosciences"}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"本田, 雅博","creatorNameLang":"ja"},{"creatorName":"ホンダ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Honda, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"本田","familyNameLang":"ja"},{"familyName":"ホンダ","familyNameLang":"ja-Kana"},{"familyName":"Honda","familyNameLang":"en"}],"givenNames":[{"givenName":"雅博","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"140154","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Several alleles of introns or untranslated regions in the presenilin-1 (PS-1) and presenilin-2 (PS-2) genes have been reported to behave as risk factors for senile Alzheimer’s disease (AD). On the other hand, mutations in the three presenile AD genes also have been identified in a small number of sporadic presenile AD and senile AD cases. The present study evaluated the genetic contributions of PS-2 exons and introns to 56 senile and 18 Japanese cases of presenile AD using polymerase chain reaction single-strand conformation polymorphism analysis. In the PS-2 gene, one exonic polymorphic site without amino acid substitution, 9 intronic polymorphic sites, and 2 intronic variant sites were detected. However, in all cases, amino acid substitutions in exons between 4 and 12 of the PS-2 gene were not observed. The risk factors of senile and presenile AD were evaluated using a population-based study of restriction cleavages between patients and controls in introns 3, 4, 10 and 11. Regarding PS-2, there was no association between AD and intronic polymorphisms.","subitem_description_type":"Other"}]},"item_14_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://onlinelibrary.wiley.com/doi/10.1046/j.1440-1819.1999.00609.x/full","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1046/j.1440-1819.1999.00609.x","subitem_relation_type_select":"DOI"}}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"114625 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成11年3月25日学位取得"},{"subitem_text_value":"原文は電子ジャーナル(URL)を参照。"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"甲博医第1235号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"本田, 雅博","creatorNameLang":"ja"},{"creatorName":"ホンダ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Honda, Masahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"本田","familyNameLang":"ja"},{"familyName":"ホンダ","familyNameLang":"ja-Kana"},{"familyName":"Honda","familyNameLang":"en"}],"givenNames":[{"givenName":"雅博","givenNameLang":"ja"},{"givenName":"マサヒロ","givenNameLang":"ja-Kana"},{"givenName":"Masahiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"140154","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-03"}],"displaytype":"detail","filename":"22_1235.pdf","filesize":[{"value":"114.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22_1235.pdf","url":"https://kumadai.repo.nii.ac.jp/record/30235/files/22_1235.pdf"},"version_id":"92c4bbdf-4dfd-4658-931b-50d7daa8c855"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer's disease","subitem_subject_scheme":"Other"},{"subitem_subject":"presenilin-2 gene","subitem_subject_scheme":"Other"},{"subitem_subject":"polymorphism","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Novel intronic polymorphisms in the presenilin-2 gene and a case-control association study of Alzheimer's disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel intronic polymorphisms in the presenilin-2 gene and a case-control association study of Alzheimer's disease"}]},"item_type_id":"14","owner":"1","path":["349"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-17"},"publish_date":"2017-10-17","publish_status":"0","recid":"30235","relation_version_is_last":true,"title":["Novel intronic polymorphisms in the presenilin-2 gene and a case-control association study of Alzheimer's disease"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-08-30T05:10:27.514006+00:00"}