@article{oai:kumadai.repo.nii.ac.jp:00030419,
 author = {鈴木, 涼馬 and Suzuki, Ryoma and 盛島, 由貴 and Tokuda, Aoi and 松永, 浩文 and Matsunaga, Yoshifumi and 山下, 太郎 and Yamashita, Taro and 冨吉, 勝美 and Tomiyoshi, Katsumi},
 journal = {熊本大学医学部保健学科紀要},
 month = {Mar},
 note = {Early detection and quantitative evaluation of deposited amyloid is extremely important in treating patients with amyloidosis. we made a precursor EMSB and 19F-EFSB labeled stable isotope fluorine on EMSB to develop a new imaging probe18F-EFSB that detects systemic amyloidosis by PET examination. In this study, the following three were carried out as basic research for clinical application of 18F-EFSB for diagnosis (1)histochemical analysis to amyloid using 19F-EFSB, (2)investigation of optimal synthesis condition of 18F-EFSB, (3)quality control of 18F-EFSB. As a result of histochemical analysis, 19F-EFSB specifically accumulated in all disease type amyloid. Therefore, it was shown that 18F-EFSB also accumulates in amyloid.18F-EFSB was efficiently labeled with a radiochemical purity of 81.7 ± 5.1%(n=3) by reaction at 200 degree for 5 minutes. Quality control (radiochemical purity test, pH measurement, endotoxin test,sterility test) performed was no problem. By clearing some quality control in the future, 18F-EFSB may be a clinically applicable tracer capable of detecting amyloid in the whole body.},
 pages = {33--41},
 title = {全身性アミロイドイメージングプローブ18F-EFSBの臨床応用に向けた基礎研究},
 volume = {14},
 year = {2018},
 yomi = {スズキ, リョウマ and モリシマ, ヨシユキ and マツナガ, ヨシフミ and ヤマシタ, タロウ and トミヨシ, カツミ}
}