{"created":"2023-06-19T09:17:40.077528+00:00","id":30419,"links":{},"metadata":{"_buckets":{"deposit":"010ae579-3b24-4525-b3b9-f976e33ae876"},"_deposit":{"created_by":12,"id":"30419","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"30419"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00030419","sets":["413:414","585:612:1255"]},"author_link":["157636","157637","157638","157639","157640"],"item_15_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"41","bibliographicPageStart":"33","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"熊本大学医学部保健学科紀要","bibliographic_titleLang":"ja"}]}]},"item_15_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Early detection and quantitative evaluation of deposited amyloid is extremely important in treating patients with amyloidosis. we made a precursor EMSB and 19F-EFSB labeled stable isotope fluorine on EMSB to develop a new imaging probe18F-EFSB that detects systemic amyloidosis by PET examination. In this study, the following three were carried out as basic research for clinical application of 18F-EFSB for diagnosis (1)histochemical analysis to amyloid using 19F-EFSB, (2)investigation of optimal synthesis condition of 18F-EFSB, (3)quality control of 18F-EFSB. As a result of histochemical analysis, 19F-EFSB specifically accumulated in all disease type amyloid. Therefore, it was shown that 18F-EFSB also accumulates in amyloid.18F-EFSB was efficiently labeled with a radiochemical purity of 81.7 ± 5.1%(n=3) by reaction at 200 degree for 5 minutes. Quality control (radiochemical purity test, pH measurement, endotoxin test,sterility test) performed was no problem. By clearing some quality control in the future, 18F-EFSB may be a clinically applicable tracer capable of detecting amyloid in the whole body.","subitem_description_type":"Other"}]},"item_15_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_15_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12010572","subitem_source_identifier_type":"NCID"}]},"item_15_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493","subitem_subject_scheme":"NDC"}]},"item_15_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"【著者所属】鈴木涼馬：熊本大学大学院保健学教育部 / 盛島由貴：熊本赤十字病院 / 松永浩文：熊本大学大学院薬学教育部先端生命医療科学部門 / 山下太郎：熊本大学大学院生命科学研究部脳神経科学講座神経内科学分野 / 冨吉勝美：熊本大学大学院生命科学研究部医用理工学分野"}]},"item_15_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 涼馬","creatorNameLang":"ja"},{"creatorName":"スズキ, リョウマ","creatorNameLang":"ja-Kana"},{"creatorName":"Suzuki, Ryoma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"盛島, 由貴","creatorNameLang":"ja"},{"creatorName":"モリシマ, ヨシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Tokuda, Aoi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松永, 浩文","creatorNameLang":"ja"},{"creatorName":"マツナガ, ヨシフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsunaga, Yoshifumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下, 太郎","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, タロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Taro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"冨吉, 勝美","creatorNameLang":"ja"},{"creatorName":"トミヨシ, カツミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tomiyoshi, Katsumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"157640","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-03"}],"displaytype":"detail","filename":"MH0014_033-041.pdf","filesize":[{"value":"949.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"MH0014_033-041.pdf","url":"https://kumadai.repo.nii.ac.jp/record/30419/files/MH0014_033-041.pdf"},"version_id":"76a6677f-89d6-4bf4-a8a8-518f1fe093de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Systemic amyloidosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Amyloid PET","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Histochemical analysis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Radiosynthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Quality control","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"全身性アミロイドイメージングプローブ18F-EFSBの臨床応用に向けた基礎研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"全身性アミロイドイメージングプローブ18F-EFSBの臨床応用に向けた基礎研究","subitem_title_language":"ja"},{"subitem_title":"ゼンシン セイ アミロイド イメージング プローブ 18F-EFSB ノ リンショウ オウヨウ ニ ムケタ キソ ケンキュウ","subitem_title_language":"ja-Kana"},{"subitem_title":"Fundamental Study for Clinical Application of Systemic Amyloid Imaging Probe 18F-EFSB","subitem_title_language":"en"}]},"item_type_id":"15","owner":"12","path":["414","1255"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-03-13"},"publish_date":"2018-03-13","publish_status":"0","recid":"30419","relation_version_is_last":true,"title":["全身性アミロイドイメージングプローブ18F-EFSBの臨床応用に向けた基礎研究"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-11T00:40:38.008195+00:00"}