@article{oai:kumadai.repo.nii.ac.jp:00030420,
 author = {柏, 昂希 and Kashiwa, Koki and 副島, 彩花 and Soejima, Ayaka and 松永, 浩文 and Matsunaga, Yoshifumi and 山下, 太郎 and Yamashita, Taro and 冨吉, 勝美 and Tomiyoshi, Katsumi},
 journal = {熊本大学医学部保健学科紀要},
 month = {Mar},
 note = {1-(2-mestyl-ethoxy) -2,5bis (styryl) benzene (EMSB) is newly synthesized and reacted with 125I with Kripffix222 to obtain 1- (125I-ethoxy) -2,5bis (styryl) benzene (125I-EISB) which is a new amyloid imaging probe that can image amyloid by Single Photon Emission Computed Tomography (SPECT). The purpose of study is to determine the optimal synthesis time and clarify stability of 125I-EISB in saline and human serum, respectively. We synthesized 125I-EISB and injected 125I-EISB into saline and human serum. We used high performance liquid chromatography (HPLC) to acquire radiochemical purity of 125I-EISB. We assess changes of radiochemical purity of 125I-EISB over time. As a result, high radioactive purity 95.88±3.19% was obtained in 10 minutes by our synthesis and the radiochemical purity was 97.83±1.40% (n=6) applying our purification system.  Radiochemical purity 24 hours later was 94.01±2.09% after injecting in saline. That was 94.23±1.20% after injecting in human serum. From these results, optimal synthesis time was determined 10 minutes and radiochemical purity of 125I-EISB was stably maintained in saline and human serum, respectively.},
 pages = {42--47},
 title = {全身性アミロイドーシス検索薬125I-EISBの研究 : 最適反応時間および安定性の検討},
 volume = {14},
 year = {2018},
 yomi = {カシワ, コウキ and ソエジマ, アヤカ and マツナガ, ヨシフミ and ヤマシタ, タロウ and トミヨシ, カツミ}
}