@article{oai:kumadai.repo.nii.ac.jp:00030499,
 author = {Indo, Yasuhiro and 犬童, 康弘 and Indo, Yasuhiro},
 journal = {Neuroscience & Biobehavioral Reviews},
 month = {Apr},
 note = {application/pdf, 論文(Article), NGF is a well-studied neurotrophic factor, and TrkA is a receptor tyrosine kinase for NGF. The NGF-TrkA system supports the survival and maintenance of NGF-dependent neurons during development. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder due to loss-of-function mutations in the NTRKI gene encoding TrkA. Individuals with CIPA lack NGF-dependent neurons, including NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. Thus, the pathophysiology of CIPA can provide intriguing findings to elucidate the unique functions that NGF-dependent neurons serve in humans, which might be difficult to evaluate in animal studies. Preceding studies have shown that the NGF-TrkA system plays critical roles in pain, itching and inflammation. This review focuses on the clinical and neurobiogical aspects of CIPA and explains that NGF-dependent neurons in the peripheral nervous system play pivotal roles in interoception and homeostasis of our body, as well as in the stress response. Furthermore, these NGF-dependent neurons are likely requisite for neurobiological processes of 'emotions and feelings' in our species., https://www.sciencedirect.com/science/article/pii/S0149763417307121?via%3Dihub},
 pages = {1--16},
 title = {NGF-dependent neurons and neurobiology of emotions and feelings : Lessons from congenital insensitivity to pain with anhidrosis},
 volume = {87},
 year = {2018},
 yomi = {インドウ, ヤスヒロ}
}