{"created":"2023-06-19T09:18:08.422479+00:00","id":31008,"links":{},"metadata":{"_buckets":{"deposit":"3d92267b-3883-4d0d-aa83-112da773dc31"},"_deposit":{"created_by":1,"id":"31008","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"31008"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00031008","sets":["413:443"]},"author_link":["143834","143832","143833","143835","143831","143830"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2755","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"Frontiers in Immunology"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松岡, 雅雄"}],"nameIdentifiers":[{"nameIdentifier":"143834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安間-水戸部, 恵子"}],"nameIdentifiers":[{"nameIdentifier":"143835","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Costimulatory and coinhibitory receptors play a key role in regulating immune responses\nto infection and cancer. Coinhibitory receptors include programmed cell death 1 (PD-1),\ncytotoxic T-lymphocyte-associated protein 4 (CTLA-4), and T cell immunoglobulin and\nITIM domain (TIGIT), which suppress immune responses. Coinhibitory receptors are\nhighly expressed on exhausted virus-specific T cells, indicating that viruses evade\nhost immune responses through enhanced expression of these molecules. Human\nretroviruses, human immunodeficiency virus (HIV) and human T-cell leukemia virus type\n1 (HTLV-1), infect T cells, macrophages and dendritic cells. Therefore, one needs to\nconsider the effects of coinhibitory receptors on both uninfected effector T cells and\ninfected target cells. Coinhibitory receptors are implicated not only in the suppression of\nimmune responses to viruses by inhibition of effector T cells, but also in the persistence\nof infected cells in vivo. Here we review recent studies on coinhibitory receptors and their\nroles in retroviral infections such as HIV and HTLV-1.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"https://www.frontiersin.org/articles/10.3389/fimmu.2018.02755/full","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Frontiers Media"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3389/fimmu.2018.02755","subitem_relation_type_select":"DOI"}}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"16643224","subitem_source_identifier_type":"ISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"419802 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsuoka, Masao"}],"nameIdentifiers":[{"nameIdentifier":"143830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuma-Mitobe, Keiko"}],"nameIdentifiers":[{"nameIdentifier":"143831","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-03"}],"displaytype":"detail","filename":"fimmu-09-02755.pdf","filesize":[{"value":"419.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"fimmu-09-02755.pdf","url":"https://kumadai.repo.nii.ac.jp/record/31008/files/fimmu-09-02755.pdf"},"version_id":"27c5e40a-8f26-4314-84e4-c897f5a627d6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"co-inhibitory receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"HTLV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"PD-1","subitem_subject_scheme":"Other"},{"subitem_subject":"TIGIT","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-15"},"publish_date":"2019-01-15","publish_status":"0","recid":"31008","relation_version_is_last":true,"title":["The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T16:52:27.099473+00:00"}