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Niphateolide A: isolation from the marine sponge Niphates olemda and determination of its absolute configuration by an ECD analysis
http://hdl.handle.net/2298/00043527
http://hdl.handle.net/2298/00043527cb428f68-04fd-42ea-be2e-ba082060b196
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0040-4020v71_6956-6960 (808.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-23 | |||||
| タイトル | ||||||
| タイトル | Niphateolide A: isolation from the marine sponge Niphates olemda and determination of its absolute configuration by an ECD analysis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Diterpene, Marine sponge, Niphates olemda, ECD analysis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Kato, Hikaru
× Kato, Hikaru× Nehira, Tetsuo× Matsuo, Koichi× Kawabata, Tetsuro× Kobashigawa, Yoshihiro× Morioka, Hiroshi× Fitje, Losung× Remy E.P., Mangindaan× Nicole J., de Voogd× Yokosawa, Hideyoshi× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | A diterpene with a new skeleton, niphateolide A (1), was isolated from the marine sponge, Niphates olemda, as an inhibitor of the p53-Hdm2 interaction. Its structure was elucidated by NMR spectroscopy and its absolute configuration was established as 10R, 11R by ECD at the vacuum-ultraviolet region with a theoretical calculation. Compound 1 was observed as an inseparable stereoisomeric mixture at C-17 and an ECD analysis was subsequently performed by adopting a virtual equilibrium between the simplified two forms, 10R,11R,17R- and 10R,11R,17S-1a, in which the calculated ECD spectra were correctively integrated with the theoretically-derived internal and free energies. | |||||
| 書誌情報 |
en : Tetrahedron 巻 71, 号 38, p. 6956-6960, 発行年 2015-09-23 |
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| ISSN | ||||||
| 収録物識別子 | 0040-4020 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.tet.2015.07.009 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2015 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 483.2 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
