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Siladenoserinols M–P, sulfonated serinol derivatives from a tunicate
http://hdl.handle.net/2298/00043529
http://hdl.handle.net/2298/00043529cd71d43d-0625-40f7-96ca-d6ede0ca38d5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0040-4020v74_7516-7521 (542.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-28 | |||||
| タイトル | ||||||
| タイトル | Siladenoserinols M–P, sulfonated serinol derivatives from a tunicate | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Tunicate, Didemnidae, Sulfonated serinol derivatives | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Torii, Masumi
× Torii, Masumi× Hitora, Yuki× Kato, Hikaru× Koyanagi, Yuhei× Kawahara, Teppei× Losung, Fitje× Mangindaan, Remy E.P.× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | Four new sulfonated serinol derivatives, siladenoserinols M–P (1–4), were isolated from a tunicate of the family Didemnidae collected in Indonesia. Their chemical structures were elucidated by the interpretation of NMR and mass spectroscopic data. Two of them (2 and 4) were revealed to be disulfonate serinol derivatives, and the others were monosulfonates. Siladenoserinols A (5) and B (6), which we previously isolated from the same tunicate, inhibited the p53–Hdm2 interaction with an IC50 value of 2.0 μM. However, 1–4 did not inhibit the activity. The result suggested that the acetyl group in the bicyclic ketal unit and/or the glycerophospholipid moiety in 5 and 6 were responsible for the inhibition of the p53–Hdm2 interaction. | |||||
| 書誌情報 |
en : Tetrahedron 巻 74, 号 52, p. 7516-7521, 発行年 2018-12-27 |
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| ISSN | ||||||
| 収録物識別子 | 0040-4020 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.tet.2018.11.031 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2018 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 485.95 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
