{"created":"2023-06-19T09:18:50.634144+00:00","id":31914,"links":{},"metadata":{"_buckets":{"deposit":"cc0276cd-2567-407f-ba9d-f658bf2cc7a6"},"_deposit":{"created_by":12,"id":"31914","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"31914"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00031914","sets":["415:416"]},"author_link":["165254","165345","165346","165249","165347","165348","165349","165350","165351","165352","165353","165263"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicPageEnd":"5317","bibliographicPageStart":"5315","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters","bibliographic_titleLang":"en"}]}]},"item_16_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmcl.2014.09.043","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2020 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"PISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"483.2","subitem_subject_scheme":"NDC"},{"subitem_subject":"499.3","subitem_subject_scheme":"NDC"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsukamoto, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Tomoharu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawabata, Tetsuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Hikaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamakuma,Michiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuo, Kanae","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"El-Desoky, Ahmed H. ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Losung, Fitje ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mangindaan, Remy E.P. ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"de Voogd, Nicole J. ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arata, Yoichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokosawa, Hideyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165263","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"0960-849v24_5315-5317.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"0960-849v24_5315-5317","url":"https://kumadai.repo.nii.ac.jp/record/31914/files/0960-849v24_5315-5317.pdf"},"version_id":"1ee2dafe-566f-4d54-a6a0-728370da52ed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Halenaquinone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclastogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Marine sponge","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Petrosia alfiani","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Halenaquinone inhibits RANKL-induced osteoclastogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Halenaquinone inhibits RANKL-induced osteoclastogenesis","subitem_title_language":"en"}]},"item_type_id":"16","owner":"12","path":["416"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"31914","relation_version_is_last":true,"title":["Halenaquinone inhibits RANKL-induced osteoclastogenesis"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-05T04:07:05.356666+00:00"}