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創薬を指向した天然薬物学研究
http://hdl.handle.net/2298/00043540
http://hdl.handle.net/2298/000435402ec10061-eb0a-457e-ae0f-af4d3a505416
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
130_1273 (843.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-26 | |||||
| タイトル | ||||||
| タイトル | 創薬を指向した天然薬物学研究 | |||||
| 言語 | ja | |||||
| タイトル | ||||||
| タイトル | ソウヤク オ シコウ シタ テンネン ヤクブツガク ケンキュウ | |||||
| 言語 | ja-Kana | |||||
| タイトル | ||||||
| タイトル | Study on Natural Products for Drug Development | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題 | ubiquitin-proteasome system, natural product, drug development, indole alkaloid, enantiomer, fungus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukamoto, Sachiko
× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | The ubiquitin-proteasome system (UPS) plays a major role in selective protein degradation and regulates various cellular events. Approval of bortezomib for the treatment of multiple myeloma validated the proteasome as an anticancer target. In order to find drug candidates targeting the ubiquitin-dependent protein degradation, we paid an attention to inhibitors against three enzymes, ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin-protein ligase (E3), which are required for polyubiquitination of proteins and prerequisite to proteasome-mediated protein degradation. We succeeded in isolating various compounds with three distinct inhibitory activities against an E1 enzyme reaction, Ubc13 (E2)-Uev1A interaction, and p53-HDM2 (E3) interaction as well as the proteasome inhibitors. We also isolated new alkaloids, notoamides, from a marine-derived Aspergillus sp. Among them, notoamide B and stephacidin A contain a bicyclo[2.2.2]diazaoctane ring in their structures. We proposed this ring is constructed from notoamide E by the intramolecular Diels-Alder (IMDA) reaction. Recently, the isolation of the antipodes of notoamides from the terrestrial Aspergillus has been reported. We propose that each enantiomer is generated by a distinct face-selective IMDA. | |||||
| 書誌情報 |
ja : 藥學雑誌 en : YAKUGAKU ZASSHI 巻 130, 号 10, p. 1273-1281, 発行年 2010-10-01 |
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| ISSN | ||||||
| 収録物識別子 | 0031-6903 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00284903 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | https://doi.org/10.1248/yakushi.130.1273 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2010 The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.39 | |||||
| 論文ID（NAID） | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 130000451669 | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
