WEKO3
アイテム
Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages
http://hdl.handle.net/2298/00043543
http://hdl.handle.net/2298/000435439fff4ec1-49d9-4251-8649-2cf1acafd334
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0960-894Xv25_5389-5392 (1.3 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-26 | |||||
| タイトル | ||||||
| タイトル | Bastadins, brominated-tyrosine derivatives, suppress accumulation of cholesterol ester in macrophages | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Bastadin, Brominated-tyrosine derivatives, Cholesterol ester, Atherosclerosis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Eguchi, Keisuke
× Eguchi, Keisuke× Kato, Hikaru× Fujiwara, Yukio× Losung, Fitje× Mangindaan, Remy E.P.× de Voogd, Nicole J.× Takeya, Motohiro× Tsukamoto, Sachiko |
|||||
| 抄録 | ||||||
| 内容記述 | The formation of foam cells in macrophages has been suggested to play an essential role in the progression of early atherosclerotic lesions in vivo and, thus, its suppression is considered to be one of the major approaches for the treatment of atherosclerosis. We isolated eight brominated-tyrosine derivatives, bastadins, from the EtOH extract of the marine sponge Ianthella vasta as inhibitors of the formation of foam cells induced by acetylated low-density lipoproteins in human monocyte-derived macrophages. Bastadin 6 was the strongest inhibitor of foam cell formation due to its suppression of acyl-coenzyme A:cholesterol acyltransferase. | |||||
| 書誌情報 |
en : Bioorganic & Medicinal Chemistry Letters 巻 25, 号 22, p. 5389-5392, 発行年 2015-11-15 |
|||||
| ISSN | ||||||
| 収録物識別子 | 0960-894X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.bmcl.2015.09.024 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2018 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 483.2 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
