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Search for Inhibitors of the Ubiquitin–Proteasome System from Natural Sources for Cancer Therapy
http://hdl.handle.net/2298/00043542
http://hdl.handle.net/2298/00043542edf1f2d4-630a-48d1-82e0-231958a5f6c4
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
64_c15-00768 (944.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-10-26 | |||||
| タイトル | ||||||
| タイトル | Search for Inhibitors of the Ubiquitin–Proteasome System from Natural Sources for Cancer Therapy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | enzyme inhibitor, proteasome, ubiquitin system, deubiquitinating enzyme, drug lead, cancer | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukamoto, Sachiko
× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | Since the approval of the proteasome inhibitor, Velcade®, by the Food and Drug Administration (FDA) for the treatment of relapsed multiple myeloma, inhibitors of the ubiquitin–proteasome system have been attracting increasing attention as promising drug leads for cancer therapy. While the development of drugs for diseases related to this proteolytic system has mainly been achieved by searching libraries of synthetic small molecules or chemical modifications to drug leads, limited searches have been conducted on natural sources. We have been searching natural sources for inhibitors that target this proteolytic system through in-house screening. Our recent studies on the search for natural inhibitors of the ubiquitin–proteasome system, particularly, inhibitors against the proteasome, E1 enzyme (Uba1), E2 enzyme (Ubc13–Uev1A heterodimer), and E3 enzyme (Hdm2), and also those against deubiquitinating enzyme (USP7), are reviewed here. | |||||
| 書誌情報 |
en : Chemical and Pharmaceutical Bulletin 巻 64, 号 2, p. 112-118, 発行年 2016-02-01 |
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| ISSN | ||||||
| 収録物識別子 | 0009-2363 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00602100 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | https://doi.org/10.1248/cpb.c15-00768 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2016 The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 論文ID（NAID） | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 130005121724 | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 | |||||
