@article{oai:kumadai.repo.nii.ac.jp:00031920, author = {Kato, Hikaru and Kai, Aika and Kawabata, Tetsuro and Sunderhaus, James D. and McAfoos, Timothy J. and Finefield, Jennifer M. and Sugimoto, Yukihiko and Williams, Robert M. and Tsukamoto, Sachiko}, issue = {22}, journal = {Bioorganic & Medicinal Chemistry Letters}, month = {Nov}, note = {The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (-)-enantiomers of notoamides A and B, 6-epi-notoamide T, and stephacidin A inhibited receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclastogenic differentiation of murine RAW264 cells more strongly than their respective (+)-enantiomers. Among them, (-)-6-epi-notoamide T was the most potent inhibitor with an IC50 value of 1.7 μM.}, pages = {4975--4978}, title = {Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts}, volume = {27}, year = {2017} }