{"created":"2023-06-19T09:18:50.917464+00:00","id":31920,"links":{},"metadata":{"_buckets":{"deposit":"9bfe826c-a224-4c6a-8f73-f2434a7120dc"},"_deposit":{"created_by":12,"id":"31920","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"31920"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00031920","sets":["415:416"]},"author_link":["165249","165321","165346","165387","165388","165389","165390","165391","165254"],"control_number":"31920","item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"22","bibliographicPageEnd":"4978","bibliographicPageStart":"4975","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters","bibliographic_titleLang":"en"}]}]},"item_16_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (-)-enantiomers of notoamides A and B, 6-epi-notoamide T, and stephacidin A inhibited receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclastogenic differentiation of murine RAW264 cells more strongly than their respective (+)-enantiomers. Among them, (-)-6-epi-notoamide T was the most potent inhibitor with an IC50 value of 1.7 μM.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bmcl.2017.10.017","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2017 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"PISSN"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"474.73","subitem_subject_scheme":"NDC"},{"subitem_subject":"499.3","subitem_subject_scheme":"NDC"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Hikaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kai, Aika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165321","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawabata, Tetsuro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunderhaus, James D.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"McAfoos, Timothy J.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Finefield, Jennifer M.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165389","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugimoto, Yukihiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165390","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Williams, Robert M.","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165391","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsukamoto, Sachiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"165254","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-26"}],"displaytype":"detail","filename":"0960-894Xv27_4975-4978.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"0960-894Xv27_4975-4978","url":"https://kumadai.repo.nii.ac.jp/record/31920/files/0960-894Xv27_4975-4978.pdf"},"version_id":"5f07033d-2d45-4d37-bacd-1d829eace74b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Notoamide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enantiomer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoclastogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Aspergillus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fungus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts","subitem_title_language":"en"}]},"item_type_id":"16","owner":"12","path":["416"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-10-26"},"publish_date":"2020-10-26","publish_status":"0","recid":"31920","relation_version_is_last":true,"title":["Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-10-16T05:25:26.092195+00:00"}