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Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens
http://hdl.handle.net/2298/00043545
http://hdl.handle.net/2298/000435457adf2586-7129-42eb-8f0b-640b7e8faff7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0960-894Xv29_8-10 (436.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2021-01-02 | |||||
| タイトル | ||||||
| タイトル | Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Proteasome inhibitor, Constitutive proteasome, Immunoproteasome, Halicyclamine, Acanthostrongylophora ingens | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kato, Hikaru
× Kato, Hikaru× El-Desoky, Ahmed H.× Takeishi, Yuya× Nehira, Tetsuo× Angkouw, Esther D.× Mangindaan, Remy E.P.× de Voogd, Nicole J.× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | A new halicyclamine derivative, tetradehydrohalicyclamine B (1), was isolated from the marine sponge Acanthostrongylophora ingens, along with halicyclamine B (2) as proteasome inhibitors. Compound 1 is the second example found to have a pyridinium ring in the halicyclamine family. Although the relative configuration of 2 was previously determined by X-ray crystallographic analysis, here we determined the absolute configuration of 2 by ECD experiment. Compounds 1 and 2 inhibited the constitutive proteasome as well as the immunoproteasome. The inhibitory activities of 2 were 4- to 10-fold more potent than those of 1. | |||||
| 書誌情報 |
en : Bioorganic & Medicinal Chemistry Letters 巻 29, 号 1, p. 8-10, 発行年 2019-01-01 |
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| ISSN | ||||||
| 収録物識別子 | 0960-894X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.bmcl.2018.11.028 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2018 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 483.2 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
