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New geranyl flavonoids from the leaves of Artocarpus communis
http://hdl.handle.net/2298/00043549
http://hdl.handle.net/2298/0004354914d5dd7a-05ae-4146-a42c-7d8e98e85979
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
1340-3443v72_632-640 (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-26 | |||||
| タイトル | ||||||
| タイトル | New geranyl flavonoids from the leaves of Artocarpus communis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Artocarpus communis, Moraceae, Geranyl flavonoid, Chiral resolution, USP7, Proteasome | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Inoue, Masamitsu
× Inoue, Masamitsu× Hitora, Yuki× Kato, Hikaru× Losung, Fitje× Mangindaan, Remy E. P.× Tsukamoto, Sachiko |
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| 抄録 | ||||||
| 内容記述 | Four new geranyl flavonoids 1–4 and four known flavonoids 5–8 were obtained from the leaves of Artocarpus communis collected in Indonesia. The planar structures of flavonoids were elucidated by analyses of MS and NMR spectroscopic data. Absolute configurations of 1 and 2 were determined by ECD spectroscopy. Analyses by HPLC with a chiral-phase column and ECD spectra confirmed that 3 and 4 were stereoisomeric mixtures and 7 and 8 were racemic mixtures. The compounds obtained in this study inhibited the enzymatic activities of ubiquitin-specific protease 7 (USP7) and the chymotrypsin-like activity of the proteasome. Among the geranyl flavonoids tested in this experiment, the USP7 inhibitory activity of 6 (IC50 value, 0.094 μM) was 55 times more potent than the commercially available positive control, P5091 (IC50 value, 5.2 μM). | |||||
| 書誌情報 |
en : Journal of Natural Medicines 巻 72, p. 632-640, 発行年 2018-02-24 |
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| ISSN | ||||||
| 収録物識別子 | 1340-3443 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1007/s11418-018-1192-z | |||||
| 権利 | ||||||
| 権利情報 | This is a post-peer-review, pre-copyedit version of an article published in Journal of Natural Medicines. The final authenticated version is available online at : https://doi.org/10.1007/s11418-018-1192-z. | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.87 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Springer Nature | |||||
