Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor.

Yumiko, Nagasawa; Reiko, Ueoka; Rumi, Yamanokuchi; Naoki, Horiuchi; Tsuyoshi, Ikeda; Henki, Rotinsulu; Remy E. P., Mangindaan; Kazuyo, Ukai; Hisayoshi, Kobayashi; Michio, Namikoshi; Hiroshi, Hirota; Hideyoshi, Yokosawa; Sachiko, Tsukamoto

doi:https://doi.org/10.1248/cpb.59.287

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Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor.

http://hdl.handle.net/2298/00043555

名前 / ファイル	ライセンス	アクション
0009-2363v59_287-290 (489.6 kB)

Item type

学術雑誌論文 / Journal Article(1)

公開日

2020-11-04

タイトル

Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor.

言語

eng

キーワード

主題

tetrahydroisoquinoline alkaloid, proteasome, chymotrypsin-like activity, marine sponge

資源タイプ

journal article

著者

Yumiko, Nagasawa
Reiko, Ueoka
Rumi, Yamanokuchi
Naoki, Horiuchi
Tsuyoshi, Ikeda
Henki, Rotinsulu
Remy E. P., Mangindaan
Kazuyo, Ukai
Hisayoshi, Kobayashi
Michio, Namikoshi
Hiroshi, Hirota
Hideyoshi, Yokosawa
Sachiko, Tsukamoto

抄録

内容記述

Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC50 values of 50 and 32 μg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 μg/ml.

書誌情報

en : Chemical and Pharmaceutical Bulletin

巻 59, 号 2, p. 287-290, 発行年 2011-02-01

ISSN

収録物識別子

0009-2363

DOI

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Ver.1

2023-06-19 14:36:38.828376

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アイテム

Isolation of Salsolinol, a Tetrahydroisoquinoline Alkaloid, from the Marine Sponge Xestospongia cf. vansoesti as a Proteasome Inhibitor.

× Yumiko, Nagasawa

× Reiko, Ueoka

× Rumi, Yamanokuchi

× Naoki, Horiuchi

× Tsuyoshi, Ikeda

× Henki, Rotinsulu

× Remy E. P., Mangindaan

× Kazuyo, Ukai

× Hisayoshi, Kobayashi

× Michio, Namikoshi

× Hiroshi, Hirota

× Hideyoshi, Yokosawa

× Sachiko, Tsukamoto

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