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Photochemical OFF/ON Cytotoxicity Switching by Using a Photochromic Surfactant with Visible Light Irradiation
http://hdl.handle.net/2298/00046393
http://hdl.handle.net/2298/00046393a01bd54c-05ee-4364-abe8-581ec66b96c7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
acsomega_1c06473.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2023-03-07 | |||||
| タイトル | ||||||
| タイトル | Photochemical OFF/ON Cytotoxicity Switching by Using a Photochromic Surfactant with Visible Light Irradiation | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
篠原, 真衣
× 篠原, 真衣× 足利, 友弥× Xu, Wei× 金, 善南× 深港, 豪× 新留, 琢郎× 栗原, 清二 |
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| 別言語の著者 |
Shinohara, Mai
× Shinohara, Mai× Ashikaga, Yuya× Xu, Wei× Kim, Sunnam× Fukaminato, Tuyoshi× Niidome, Takuro× Kurihara, Seiji |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Photochemical switching of cytotoxicity by using spiropyran compounds with pyridinium and alkyl groups was investigated. The spiropyran compound, SP6, with a hexyl group as the alkyl group displayed negative photochromism, in which the hydrophilic open merocyanine form (MC form) was stable and isomerized to the hydrophobic closed spiro form (SP form) by visible light irradiation. Both MC and SP forms exhibited amphiphilicity because of the hydrophobic hexyl and hydrophilic pyridinium groups introduced. Cytotoxicity toward HeLa cells was observed for both MC and SP forms of SP6 at concentrations higher than the critical aggregation concentration of the isomers CACMC and CACSP (CACMC > CACSP), respectively. In contrast, cytotoxicity by SP6 was activated by visible light irradiation at concentrations between CACMC and CACSP; thus, photochemical switching of cytotoxicity from the OFF to ON state was achieved. Cytotoxicity was revealed to be caused by disruption of the cell membrane. The results provide an important step in developing novel next-generation photochemotherapy drugs. | |||||
| 書誌情報 |
ACS omega 巻 7, 号 7, p. 6093-6098, 発行年 2022-02-22 |
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| ISSN | ||||||
| 収録物識別子 | 2470-1343 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1021/acsomega.1c06473 | |||||
| 権利 | ||||||
| 権利情報 | (C)2022 The Authors. Published by American Chemical Society | |||||
| 権利 | ||||||
| 権利情報 | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
