WEKO3
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Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate
http://hdl.handle.net/2298/8475
http://hdl.handle.net/2298/8475ef82b9c0-51c5-424e-941a-67c783a5ce96
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Nature CB Suppltext (Final).pdf (495.2 kB)
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Nature CB (Final).pdf (783.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-07-24 | |||||
タイトル | ||||||
タイトル | Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate | |||||
言語 | ||||||
言語 | eng | |||||
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資源タイプ | journal article | |||||
著者 |
澤, 智裕
× 澤, 智裕× ザキ, モハマド ハサン× 岡本, 竜哉× 芥, 照夫× 徳冨, 芳子× 光山, 勝慶× 居原, 秀× 小林, 章× ヤマモト, マサユキ× 藤井, 重元× アリモト, ヒデカズ× 赤池, 孝章 |
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別言語の著者 |
澤, 智裕
× 澤, 智裕× 岡本, 竜哉× 芥, 照夫× 徳冨, 芳子× 光山, 勝慶× 藤井, 重元× 赤池, 孝章 |
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内容記述 | ||||||
内容記述 | The signaling pathway of nitric oxide (NO) depends mainly on guanosine 3′,5′-cyclic monophosphate (cGMP, 1). Here we report the formation and chemical biology of a nitrated derivative of cGMP, 8-nitroguanosine 3′,5′-cyclic monophosphate (8-nitro-cGMP, 2), in NO-mediated signal transduction. Immunocytochemistry demonstrated marked 8-nitro-cGMP production in various cultured cells in an NO-dependent manner. This finding was confirmed by HPLC plus electrochemical detection and tandem mass spectrometry. 8-Nitro-cGMP activated cGMP-dependent protein kinase and showed unique redox-active properties independent of cGMP activity. Formation of protein Cys-cGMP adducts by 8-nitro-cGMP was identified as a new post-translational modification, which we call protein S-guanylation. 8-Nitro-cGMP seems to regulate the redox-sensor signaling protein Keap1, via S-guanylation of the highly nucleophilic cysteine sulfhydryls of Keap1. This study reveals 8-nitro-cGMP to be a second messenger of NO and sheds light on new areas of the physiology and chemical biology of signal transduction by NO. | |||||
書誌情報 |
Nature Chemical Biology 巻 3, 号 11, p. 727-735, 発行年 2007-11 |
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収録物識別子 | AA11994319 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1038/nchembio.2007.33 | |||||
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権利情報 | c2007 Nature Publishing Group | |||||
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関連名称 | 15524450 | |||||
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内容記述 | application/pdf | |||||
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内容記述 | application/pdf | |||||
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出版タイプ | AM | |||||
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主題 | 491.7 | |||||
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出版者 | Nature Publishing Group | |||||
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内容記述 | 論文(Article) | |||||
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雑誌掲載論文 | ||||||
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著作の一部 | ||||||
関連名称 | http://www.nature.com/nchembio/journal/v3/n11/index.html | |||||
著作の一部 | ||||||
関連名称 | http://kumadai-bisei.com/information/_nature_chemical_biology.html | |||||
コメント | ||||||
New pathways for NO signaling (A cover of "Nature Chemical Biology" vol.3, issue 11, 2007) |