WEKO3
アイテム
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults
http://hdl.handle.net/2298/10012
http://hdl.handle.net/2298/10012816c3ad5-0623-4636-a229-4c3f97fe9bd1
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Bio Pha0073-0550.pdf (491.1 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-12-02 | |||||
| タイトル | ||||||
| タイトル | Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | DNA damage, Dopamine neuron, Mitochondrial dysfunction, Neuroinflammation, Oxidative stress, Parkinson's disease | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Okawara, Mitsugu
× Okawara, Mitsugu× 香月, 博志× Kurimoto, Emi× Shibata, Haruki× 久米, 利明× 赤池, 昭紀 |
|||||
| 別言語の著者 |
大川原, 賦
× 大川原, 賦× 香月, 博志× 栗本, 恵実× 柴田, 治樹× 久米, 利明× 赤池, 昭紀 |
|||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Increasing lines of evidence show that resveratrol, a polyphenol compound contained in several dietary products, exhibits cytoprotective actions. Notably, resveratrol activates sirtuin family of NAD-dependent histone deacetylases implicated in regulation of various cellular processes including gene transcription, DNA repair and apoptosis. Here we examined neuroprotective effect of resveratrol on dopaminergic neurons in organotypic midbrain slice culture. Resveratrol and quercetin, another sirtuin-activating polyphenol, prevented the decrease of dopaminergic neurons and the increase of propidium iodide uptake into slices induced by a dopaminergic neurotoxin 1-methyl-4-phenyl pyridinium (MPP+). Resveratrol also provided concentration-dependent neuroprotective effects against sodium azide, a mitochondrial complex IV inhibitor, and thrombin (EC number 3.4.21.5), a microglia-activating agent. Sirtuin inhibitors such as nicotinamide and sirtinol did not attenuate the protective effect of resveratrol against MPP+ cytotoxicity. Instead, we found that resveratrol prevented accumulation of reactive oxygen species, depletion of cellular glutathione, and cellular oxidative damage induced by MPP+, suggesting involvement of antioxidative properties in the neuroprotective action of resveratrol. On the other hand, resveratrol as well as a sirtuin activator NAD inhibited dopaminergic neurotoxicity of a DNA alkylating agent, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Moreover, MNNG-induced increase in acetylation of p53, a representative target of sirtuin deacetylase activity, was suppressed by resveratrol. These results indicate that resveratrol can exert neuroprotective actions in dopaminergic neurons. Either antioxidative activity or sirtuin-activating potential may play an important role in the neuroprotectice actions of resveratrol against different kinds of insults. | |||||
| 書誌情報 |
Biochemical Pharmacology 巻 73, 号 4, p. 550-560, 発行年 2007-02-15 |
|||||
| ISSN | ||||||
| 収録物識別子 | 00062952 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00564486 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.bcp.2006.11.003 | |||||
| 権利 | ||||||
| 権利情報 | © 2006 Elsevier Inc. All rights reserved. | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 491117 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.17 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier Inc | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| 部分である | ||||||
| 関連タイプ | isPartOf | |||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://hdl.handle.net/2298/9868 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.elsevier.com/locate/biochempharm | |||||
| コメント | ||||||
| 値 | 平成18～19年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号:18590052『ミクログリアの活性化を介する黒質線条体系ニューロン変性の機序とその防御』pp.88-98に掲載 | |||||
