| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-02-16 |
| タイトル |
|
|
タイトル |
Therapeutic effects of γ-irradiation in a primary effusion lymphoma mouse model |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
primary effussion lymphoma, radiosensitivity, animal model |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
白石, 善興
後藤, 久美子
砥綿, 知美
島﨑, 達也
鈴, 伸也
古嶋, 昭博
岡田, 誠治
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Primary effusion lymphoma (PEL) is a unique and recently identified non-Hodgkin's lymphoma in immuno-compromised individuals. PEL is caused by the Kaposi sarcoma-associated herpes virus/human herpes virus 8 (KSHV/HHV-8) and has a peculiar presentation involving liquid growth in the serous body cavity, chemotherapy resistance and poor prognosis. In search of a new therapeutic modality for PEL, we examined the effect of γ-irradiation on PEL-derived cell lines (BCBL-1, BC-1, and BC-3) in vitro and in vivo. An MTT assay and trypan blue exclusion assay revealed that irradiation significantly suppressed cell proliferation in the PEL cell lines in a dose-dependent manner, and induced apoptosis. The PEL cell lines were relatively radiosensitive compared with other hematological tumor cell lines (Raji, Jurkat, and K562 cells). Inoculation of the BC‑3 cell line into the peritoneal cavity of Rag2/Jak3 double-deficient mice led to massive ascites formation, and subcutaneous injection of BCBL-1 led to solid lymphoma formation. Total body irradiation (4 Gy x 2) with bone marrow transplantation resulted in the complete recovery of both types of PEL-inoculated mice. These results suggest that total body irradiation with bone marrow transplantation can be successfully applied for the treatment of chemotherapyresistant PEL. |
| bibliographic_information |
en : EXPERIMENTAL AND THERAPEUTIC MEDICINE
巻 1,
号 1(January-February 2010),
p. 79-84,
発行年 2010-01
|
| item_16_source_id_7 |
|
|
収録物識別子 |
1792-0981 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 日本十進分類法 |
|
|
主題Scheme |
NDC |
|
主題 |
492 |
| 出版者 |
|
|
出版者 |
Spandidos Publications |
| 関連 |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3892/etm_00000014 |
78.Shiraishi-r.pdf (523.5 kB)
