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Effect of dose timing in relation to food intake on systemic exposure to blonanserin
http://hdl.handle.net/2298/19178
http://hdl.handle.net/2298/19178cb6d74f8-a147-4cba-bdb4-86c2038cd046
| 名前 / ファイル | ライセンス | アクション |
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Manuscript Eur J Clin Pharmacol blonanserin_r.pdf (118.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-05-30 | |||||
| タイトル | ||||||
| タイトル | Effect of dose timing in relation to food intake on systemic exposure to blonanserin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | food, time, dopamine D2 and serotonin 5-HT2 antagonist, blonanserin, systemic exposure | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Saruwatari, Junji
× Saruwatari, Junji× Yasui-Furukori, Norio× Inoue, Yoshimasa× Kaneko, Sunao |
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| 別言語の著者 |
猿渡, 淳二
× 猿渡, 淳二× 古郡, 規雄 |
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| 内容記述 | ||||||
| 内容記述 | Purpose Blonanserin is a novel potent dopamine D2 and serotonin 5-HT2 antagonist for treating schizophrenia. The aim of this study was to investigate prandial effects on systemic exposure to blonanserin in healthy volunteers, with particular attention paid to the effect of dose timing relative to meal intake. Methods Volunteers received a single 2-mg oral dose of blonanserin under the following conditions: fasting, 30 min before eating a standard meal; or 30 min or 2 or 4 h after eating the meal. Plasma concentrations of blonanserin were measured using validated high-performance liquid chromatography coupled with tandem mass spectrometry. Results Ratios and 90% confidence intervals of the geometric means compared with the fasting condition indicated that the maximum concentrations of blonanserin (Cmax) significantly increased with dosing 30 min before meal intake, and 30 min and 2 and 4 h after meal intake, yielding by 330%, 239%, 272%, and 138%, respectively. The truncated area under the concentration-time curve (AUClast) also increased by 386%, 201%, 256%, and 155%, respectively. There was no difference in values of the time to reach maximum concentration between the fasting and the four fed states. Conclusions Food intake increased the systemic exposure to blonanserin for all time intervals investigated in this study. The marked effect of food on the bioavailability of blonanserin should be taken into account in its dosing schedules. |
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| 書誌情報 |
European Journal of Clinical Pharmacology 巻 66, 号 9, p. 899-902, 発行年 2010-09 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20490472 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s00228-010-0834-1 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Springer-Verlag | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 00316970 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 118833 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 出版者 | ||||||
| 出版者 | Springer-Verlag | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/g745431pu845u759/ | |||||
