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Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101
http://hdl.handle.net/2298/17854
http://hdl.handle.net/2298/17854dc8b7130-d555-4afc-991a-1bbd1c342ec7
| 名前 / ファイル | ライセンス | アクション |
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JOV2010_84_14_Suppl_table&Fig.pdf (559.1 kB)
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JOV2010_84_14_7151-7160.pdf (847.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-02-02 | |||||
| タイトル | ||||||
| タイトル | Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kawashima, Yuka
× Kawashima, Yuka× Kuse, Nozomi× Gatanaga, Hiroyuki× Naruto, Takuya× Fujiwara, Mamoru× Dohki, Sachi× 赤星, 智寛× Maenaka, Katsumi× Goulder, Philip× Oka, Shinichi× Takiguchi, Masafumi |
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| 別言語の著者 |
川島, 夕佳
× 川島, 夕佳× 久世, 望× 潟永, 博之× 成戸, 卓也× 藤原, 守× 道木, 佐知× 赤星, 智寛× 前仲, 勝実× 岡, 慎一× 滝口, 雅文 |
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| 内容記述 | ||||||
| 内容記述 | HLA-B*51 alleles are reported to be associated with slow disease progression to AIDS, but the mechanism underlying this association is still unclear. In the present study, we analyzed the effect of HLA-B*5101 on clinical outcome for Japanese hemophiliacs who had been infected with HIV-1 before 1985 and had been recruited in 1998 for this study. HLA-B*5101 + hemophiliacs exhibited significantly slow progression. The analysis of HLA-B*5101-restricted HIV-1-specific cytotoxic T-lymphocyte (CTL) responses to 4 HLA-B*-restricted epitopes in 10 antiretroviral-therapy (ART)-free HLA-B*5101+ hemophiliacs showed that the frequency of Pol283-8-specific CD8+ T cells was inversely correlated with the viral load, whereas the frequencies of CD8+ T cells specific for 3 other epitopes were positively correlated with the viral load. The HLA-B*5101+ hemophiliacs whose HIV-1 replication had been controlled for approximately 25 years had HIV-1 possessing the wild-type Pol283-8 sequence or the Pol283-8V mutant, which does not critically affect T-cell recognition, whereas other HLA-B*5101+ hemophiliacs had HIV-1 with escape mutations in this epitope. The results suggest that the control of HIV-1 over approximately 25 years in HLA-B*5101-positive hemophiliacs is associated with a Pol283-8-specific CD8+ T-cell response and that lack of control of HIV-1 is associated with the appearance of Pol283-8-specific escape mutants. | |||||
| 書誌情報 |
Journal of Virology 巻 84, 号 14, p. 7151-7160, 発行年 2010-07 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1128/JVI.00171-10 | |||||
| 権利 | ||||||
| 権利情報 | © 2010, American Society for Microbiology. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 0022538X | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 0022538X | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 847055 bytes | ||||||
| 形態 | ||||||
| 559076 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.878 | |||||
| 出版者 | ||||||
| 出版者 | American Society for Microbiology | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://jvi.asm.org/cgi/content/abstract/84/14/7151 | |||||
