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"Just Make It Lower" Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients – LDL-Cholesterol: The Lower, the Better; Is It True for Asians? (Con) –
http://hdl.handle.net/2298/19401
http://hdl.handle.net/2298/19401d31a97cb-255c-4536-8648-639c659c9c3f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
74_1731.pdf (1.8 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-06-08 | |||||
| タイトル | ||||||
| タイトル | "Just Make It Lower" Is an Alternative Strategy of Lipid-Lowering Therapy With Statins in Japanese Patients – LDL-Cholesterol: The Lower, the Better; Is It True for Asians? (Con) – | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cardiovascular diseases, Japanese, Prevention, Statins | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
坂本, 知浩
× 坂本, 知浩× 小川, 久雄 |
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| 別言語の著者 |
坂本, 知浩
× 坂本, 知浩× 小川, 久雄 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | It is well known that statins improve the prognosis of cardiovascular diseases (CVD). Recent randomized control trials (RCTs) of statins conducted in Western countries revealed greater avoidance of cardiovascular events if low-density-lipoprotein cholesterol (LDL-C) reached lower levels. However, it is obvious that this evidence cannot be unconditionally extrapolated to Asians because there are great differences between Japanese and Caucasians in the absolute onset rate of CVD. Results of RCTs with Japanese for primary or secondary prevention of cardiovascular events indicate that we could benefit from statins with a relatively higher target LDL-C as compared with Western populations. In this situation, not only strong but also standard statins are still advantageous and the so-called pleiotropic effects of the drugs come to the fore. In this review, we first discuss differences in the absolute event rate in different populations, and then the lack of evidence for recommended LDL-C treatment targets, particularly in Japanese, although there is reliable evidence for reductions in plaque volume in coronary arteries from RCTs recently conducted in Japan with aggressive lipid-lowering therapy with strong statins. Finally, based on recent data, we propose a new concept regarding the secondary prevention of CVD for current Japanese populations. | |||||
| 書誌情報 |
Circulation Journal 巻 74, 号 8, p. 1731-1741, 発行年 2010-07-17 |
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| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1253/circj.CJ-10-0537 | |||||
| 権利 | ||||||
| 権利情報 | (c) 2010 THE JAPANESE CIRCULATION SOCIETY | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 1346-9843 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 1811406 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.2 | |||||
| 出版者 | ||||||
| 出版者 | THE JAPANESE CIRCULATION SOCIETY | |||||
| 別言語の出版者 | ||||||
| 値 | 社団法人 日本循環器学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.jstage.jst.go.jp/article/circj/74/8/74_1731/_article/-char/ja/ | |||||
