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Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia
http://hdl.handle.net/2298/23261
http://hdl.handle.net/2298/23261f108e67a-4625-432d-b2dc-f7045449f03f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
CPT_90_1_157–163.pdf (218.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-27 | |||||
| タイトル | ||||||
| タイトル | Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | imatinib, SLCO1A2, polymorphisms, pharmacogenetics | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamakawa, Yuji
× Yamakawa, Yuji× 濱田, 哲暢× Shuto, Tsuyoshi× Yuki, Misato× Uchida, Takashi× Kai, Hirofumi× Kawaguchi, Tatsuya× Saito, Hideyuki |
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| 別言語の著者 |
山川, 裕司
× 山川, 裕司× 濱田, 哲暢× 首藤, 剛× 結城, 美里× 内田, 隆× 甲斐, 広文× 川口, 辰哉× 齋藤, 秀之 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The purpose of this study was to explore the role of the organic-anion transporting polypeptide (OATP) 1A2 that is encoded by SLCO1A2, in the cellular uptake of the BCR-ABL tyrosine kinase inhibitor imatinib, and the relationship between SLCO1A2 polymorphisms and the pharmacokinetics of imatinib in chronic myeloid leukemia (CML) patients. Imatinib uptake was significantly enhanced in OATP1A2-transfected human embryonic kidney (HEK)293 cells (P=0.002). Naringin, an OATP1A2 inhibitor, decreased the transport of imatinib in OATP1A2-transfected HEK293, the human intestinal cell line Caco-2, and the CML cell line K562 cells. Linkage disequilibrium was found between the SLCO1A2 -1105G>A and -1032G>A genotypes in 34 CML patients and 100 healthy subjects. Imatinib clearance of CML patients was influenced by the SLCO1A2 -1105G>A/-1032G>A genotype (P=0.075) and the SLCO1A2 -361GG genotype (P=0.005). These findings suggest that imatinib is transported into cells by OATP1A2, and that SLCO1A2 polymorphisms significantly affect imatinib pharmacokinetics. | |||||
| 書誌情報 |
Clinical Pharmacology and Therapeutics 巻 90, 号 1, p. 157-163, 発行年 2011-07-01 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1038/clpt.2011.102 | |||||
| 権利 | ||||||
| 権利情報 | © 2011 American Society for Clinical Pharmacology and Therapeutics | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 00099236 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 218180 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.nature.com/clpt/journal/v90/n1/full/clpt2011102a.html | |||||
