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An anti-Parkinson drug ropinirole depletes orexin from rat hypothalamic slice culture
http://hdl.handle.net/2298/19981
http://hdl.handle.net/2298/19981ae7cc6dc-042a-453d-bdef-2ef4b5318f9d
| 名前 / ファイル | ライセンス | アクション |
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NR_68_4_figures.pdf (1.5 MB)
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NR_68_4_315-321.pdf (56.5 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-07-04 | |||||
| タイトル | ||||||
| タイトル | An anti-Parkinson drug ropinirole depletes orexin from rat hypothalamic slice culture | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Hypocretin, Melanin-concentrating hormone, Sleep attack, Ropinirole, Talipexole, Pramipexole, c-Fos | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Michinaga, Shotaro
× Michinaga, Shotaro× Hisatsune, Akinori× Isohama, Yoichiro× 香月, 博志 |
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| 別言語の著者 |
道永, 昌太郎
× 道永, 昌太郎× 久恒, 昭哲× 礒濱, 洋一郎× 香月, 博志 |
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| 内容記述 | ||||||
| 内容記述 | Non-ergot-type dopamine receptor agonists such as ropinirole are used for the treatment of Parkinson disease, but they occasionally show serious side effects including sleep attacks and daytime sleepiness. These symptoms are reminiscent of narcolepsy, a major sleep disorder. Because narcolepsy is thought to result from deficiency of a hypothalamic neuropeptide orexin, we examined whether ropinirole affected the integrity of orexin-containing neurons, using organotypic slice culture of rat hypothalamus. Application of ropinirole induced a significant decrease in the number of orexin-immunoreactive neurons. The same treatment showed no significant effect on the number of melanin-concentrating hormone-immunoreactive neurons. The decrease of orexin-immunoreactive neurons was reversible after washout of ropinirole and was not accompanied by induction of cell death. Antagonism of dopamine D2 receptors and of serotonin 5-HT1A receptors attenuated the effect of ropinirole, suggesting involvement of these receptors in depletion of orexin. On the other hand, a moderate concentration of N-methyl-d-aspartate that excited orexin neurons counteracted the effect of ropinirole on the number of orexin-immunoreactive neurons. These results suggest that ropinirole can cause deficiency of orexin by inhibiting excitatory activities of orexin neurons, which may be relevant to the adverse actions of this drug on sleep and wakefulness. | |||||
| 書誌情報 |
Neuroscience Research 巻 68, 号 4, p. 315-321, 発行年 2010-12 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20727917 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.neures.2010.08.005 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 Elsevier Ireland Ltd | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 01680102 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 56455 bytes | ||||||
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| 1514748 bytes | ||||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.17 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.5 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.sciencedirect.com/science/article/pii/S016801021002777X | |||||
