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Cardiac 123I-MIBG scintigraphy as an outcome-predicting tool for subthalamic nucleus stimulation in Parkinson's disease
http://hdl.handle.net/2298/22847
http://hdl.handle.net/2298/228471c909914-12a7-4443-b9f4-4286a4c71dbb
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AN_152_12_Fig.1.pdf (210.1 kB)
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AN_152_12_Table1-2.pdf (284.6 kB)
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AN_152_12_2063-2068.pdf (168.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-06 | |||||
| タイトル | ||||||
| タイトル | Cardiac 123I-MIBG scintigraphy as an outcome-predicting tool for subthalamic nucleus stimulation in Parkinson's disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Deep-brain stimulation, 123I-MIBG, Parkinson's disease, Subthalamic nucleus | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
山田, 和慶
× 山田, 和慶× Shiraishi, Shin-ya× Hamasaki, Tadashi× Kuratsu, Jun-ichi |
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| 別言語の著者 |
山田, 和慶
× 山田, 和慶× 白石, 愼哉× 浜崎, 禎× 倉津, 純一 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Background 123I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is a useful tool for differentiating idiopathic Parkinson's disease (PD) from other parkinsonian syndromes, but its prognostic value in PD has not been established. The objective of this study was to clarify the correlation between cardiac MIBG uptake parameters and the outcome in PD patients subjected to the subthalamic nucleus stimulation. Method We enrolled 31 consecutive PD patients and calculated the heart-to-mediastinum ratio (H/M) and washout rate (WR) based on the activity measured at 15 min (early phase) and 3 h (delayed phase) after the intravenous injection of MIBG (111 MBq). Cardinal motor symptoms and activity of daily living (ADL) were assessed on the Unified Parkinson's Disease Rating Scale (UPDRS) and Schwab and England (S-E) ADL scale, before and 3 months after surgery. Findings Neither early nor delayed H/M correlated with any of the preoperative subscores on the UPDRS or S-E, nor with postoperative outcome. On the other hand, increased WR was a positive predictor for postoperative improvement rate on S-E in medication-off state (p=0.00003). Also, WR showed a more faint but significant correlation with preoperative levodopa responsiveness on S-E (p=0.008). Conclusion Our findings suggest that 123I-MIBG scintigraphy in combination with levodopa-responsiveness evaluation may represent a useful tool for prediction of outcomes in patients subjected to STN stimulation. | |||||
| 書誌情報 |
Acta Neurochirurgica 巻 152, 号 12, p. 2063-2068, 発行年 2010-12 |
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| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s00701-010-0825-0 | |||||
| 権利 | ||||||
| 権利情報 | © Springer-Verlag 2010. | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 00016268 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 値 | 168825 bytes | |||||
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| 値 | 284639 bytes | |||||
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| 値 | 210084 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 494.627 | |||||
| 出版者 | ||||||
| 出版者 | Springer-Verlag | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
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| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/n141773625351836/ | |||||
