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Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wistar-Imamichi rats
http://hdl.handle.net/2298/25965
http://hdl.handle.net/2298/25965174cfcf5-0bbd-4eed-ba15-189e9104efa3
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2012-11-30 | |||||
| タイトル | ||||||
| タイトル | Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wistar-Imamichi rats | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題 | Cadmium, Testicular toxicity, Susceptibility, Strain difference, Genetic analysis, Inbred rat | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
島田, 秀昭
× 島田, 秀昭× Hata, Iori× Hashiguchi, Takashi× 今村, 順茂 |
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| 別言語の著者 |
島田, 秀昭
× 島田, 秀昭× 羽田, 伊織× 橋口, 敬志× 今村, 順茂 |
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| 内容記述 | ||||||
| 内容記述 | We have previously reported that inbred Wistar-Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced testicular toxicity compared to inbred Fischer 344 (F344) rats. The present study was to elucidate the genetic background of resistance to Cd-induced testicular toxicity in WI rats. The genetic analysis of susceptibility to Cd-induced testicular toxicity was conducted, by using Cd-resistant WI and Cd-sensitive F344 strains as the parental rats, and by using the testicular hemoglobin level as the indicator. In the frequency distribution of testicular hemoglobin levels in parental, first filial (F1) and second filial (F2) rats treated with Cd at a dose of 2.0 mg/kg, F1 rats had testicular hemoglobin levels intermediate to WI and F344 rats, and F2 rats segregated into three groups of low, intermediate and high phenotypes at the expected ratio. Furthermore, the backcross progeny between WI and F1 or between F344 and F1 segregated into two groups with the expected ratio. Based on a simple Mendelian genetic analysis, these segregation patterns lead us to conclude that two co-dominant alleles at a gene locus are responsible for the susceptibility to Cd-induced testicular toxicity in rats. This is the first report for the genetic analysis of susceptibility to Cd-induced testicular toxicity in inbred rat strains. | |||||
| 書誌情報 |
Archives of Toxicology 巻 85, 号 10, p. 1195-1199, 発行年 2011-10 |
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| ISSN | ||||||
| 収録物識別子 | 0340-5761 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s00204-011-0662-9 | |||||
| 権利 | ||||||
| 権利情報 | © 2011 Springer | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 490 | |||||
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| 出版者 | Springer | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 雑誌掲載論文 | ||||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/p412h850t3pw0v55/?MUD=MP | |||||
