WEKO3
アイテム
RPN2 expression predicts response to docetaxel in oesophageal squamous cell carcinoma
http://hdl.handle.net/2298/28430
http://hdl.handle.net/2298/2843094b98e93-2c7f-45e5-877d-8fbd5fe672c5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Table+supplement.pdf (22.0 kB)
|
|
|
|
Table.pdf (67.9 kB)
|
|
|
|
Figure.pdf (377.6 kB)
|
|
|
|
Article.pdf (140.5 kB)
|
|
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2013-07-05 | |||||
| タイトル | ||||||
| タイトル | RPN2 expression predicts response to docetaxel in oesophageal squamous cell carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | docetaxel, neoadjuvant chemotherapy, ESCC, RPN2, predictive marker | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Kurashige, Junji
× Kurashige, Junji× Watanabe, Masayuki× Iwatsuki, Masaaki× Kinoshita, Koichi× Saito, Seiya× Nagai, Yohei× Ishimoto, Takatsugu× Baba, Yoshifumi× Mimori, Koshi× Baba, Hideo |
|||||
| 内容記述 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Neoadjuvant chemotherapy – often using docetaxel in various combinatorial regimens – is a standard treatment choice for advanced oesophageal squamous cell carcinoma (ESCC) in Japan. However, no useful markers exist that predict docetaxel’s effects on ESCC. Ribophorin II (RPN2) silencing, which reduces glycosylation of P-glycoproteins and decreases membrane localisation, promotes docetaxel-dependent apoptosis. We investigated whether RPN2 expression in ESCC biopsy specimens could be a predictive biomarker in docetaxel-based neoadjuvant chemotherapy. Methods: We evaluated RPN2 expression immunohistochemically in biopsy specimens from 79 patients with node-positive ESCC, who received docetaxel-based adjuvant chemotherapy, and compared clinical and pathological responses between the RPN2-positive and RPN2-negative groups. We also studied susceptibility of RPN2-suppressed ESCC cells to docetaxel. Results: The RPN2-negative group had better clinical and pathological responses to docetaxel than the RPN2-positive group. We also found RPN2 suppression to alter docetaxel susceptibility in vitro. Conclusion: Expression of RPN2 in biopsy specimens could be a useful predictive marker for response to docetaxel-based neoadjuvant chemotherapy in ESCC. |
|||||
| bibliographic_information |
en : British Journal of Cancer 巻 107, 号 8, p. 1233-1238, 発行日 2012-10 |
|||||
| item_24_source_id_7 | ||||||
| 収録物識別子 | 0007-0920 | |||||
| 権利 | ||||||
| 言語 | en | |||||
| 権利情報 | (C) 2012 Nature Publishing Group | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 言語 | en | |||||
| 関連 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1038/bjc.2012.396 | |||||
