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A possible mechanism of resistance to cadmium toxicity in male Long-Evans rats
http://hdl.handle.net/2298/27263
http://hdl.handle.net/2298/27263bb447ff8-2ef8-467a-bde8-c46de911269b
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Fig. 4 pdf.pdf (9.1 kB)
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Fig. 3 pdf.pdf (8.6 kB)
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Fig. 2 pdf.pdf (8.8 kB)
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Fig. 1 pdf.pdf (8.4 kB)
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Environmental.Toxicol.Pharmacol.21.231-234.pdf (30.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-03-13 | |||||
| タイトル | ||||||
| タイトル | A possible mechanism of resistance to cadmium toxicity in male Long-Evans rats | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Cadmium, Resistance, Metallothionein, Long-Evans rat, Tissue accumulation, Zinc | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Takamure, Yasutaka
× Takamure, Yasutaka× 島田, 秀昭× 淨住, 護雄× Yasutake, Akira× 今村, 順茂 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The susceptibility to cadmium (Cd)-induced toxicity in male Long-Evans (LE) rats was compared with that in male Fischer 344 (Fischer) and Wistar-Imamichi (WI) rats, which are sensitive and resistant, respectively, to Cd toxicity. All rats of the LE and WI strains survived for 7 days after the treatment with a toxic dose of Cd (6.5 mg/kg b.w.). However, all rats of the Fischer strain died by the following day. The strong resistance to Cd toxicity in the LE strain was confirmed to be independent of metallothionein synthesis induced by Cd. The hepatic and renal Cd contents after its administration were significantly lower in the LE strain than in the Fischer strain. Furthermore, the hepatic and renal zinc (Zn) contents after its administration were significantly lower in the LE strain than in the Fischer strain. These limited data suggest that the strong resistance to Cd toxicity in male LE rats results from, at least in part, the lower accumulation of the metal in the liver and kidney, in a similar mechanism as the lower Zn accumulation. | |||||
| 書誌情報 |
en : Environmental Toxicology and Pharmacology 巻 21, 号 3, p. 231-234, 発行年 2006-05 |
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| ISSN | ||||||
| 収録物識別子 | 1382-6689 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.etap.2005.08.003 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2006 Elsevier | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
