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Effects of Chelating Agents on Distribution and Excretion of Terbium in Mice
http://hdl.handle.net/2298/27281
http://hdl.handle.net/2298/272814a9f5209-2e98-4b1e-bba7-95ec452ff650
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2013-03-15 | |||||
| タイトル | ||||||
| タイトル | Effects of Chelating Agents on Distribution and Excretion of Terbium in Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | chelating agent, distribution, excretion, terbium | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
島田, 秀昭
× 島田, 秀昭× Nagano, Masaaki× Funakoshi, Takayuki× 今村, 順茂 |
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| 別言語の著者 |
島田, 秀昭
× 島田, 秀昭× 永野, 匡昭× 船越, 崇行× 今村, 順茂 |
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| 内容記述 | ||||||
| 内容記述 | When terbium chloride (TbCl 3) was intravenously injected into mice, terbium (Tb) was mainly distributed into the spleen, lung, and liver. Thus, the effects of five chelating agents on the distribution of Tb to the spleen, lung, and liver of mice were examined. The treatments with diethyldithiocarbamate (DDTC), N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) and 2,3-dimercaptopropanol (BAL) reduced the content of Tb in the spleen. The treatments with D-penicillamine (D-PEN), ethylenediaminetetraacetic acid (EDTA), and MeOBGD reduced the content of Tb in the lung. However, BAL treatment enhanced the content of Tb in the lung, indicating the redistribution of Tb to the tissue. Although the biliary excretion of Tb was significantly increased in mice treated with EDTA and MeOBGD, these increases were negligibly small, and the metal was not detected in the urine. These results indicate that well-known chelating agents such as D-PEN, EDTA, DDTC, MeOBGD, and BAL have little ability to excrete Tb into the bile and urine. Further studies are necessary to develop a new type of chelating agent to remove Tb effectively from the body. | |||||
| 書誌情報 |
Toxicology Mechanisms and Methods 巻 15, 号 3, p. 181-184, 発行年 2005-05 |
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| ISSN | ||||||
| 収録物識別子 | 15376524 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1080/15376520590945595 | |||||
| 権利 | ||||||
| 権利情報 | © 2005 Informa Healthcare | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
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| 出版者 | Informa Healthcare | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://informahealthcare.com/doi/abs/10.1080/15376520590945595 | |||||
