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Neurobiology of pain, interoception and emotional response: lessons from nerve growth factor-dependent neurons
http://hdl.handle.net/2298/32861
http://hdl.handle.net/2298/32861976e4230-2a24-42f5-b269-15972ea339a0
| 名前 / ファイル | ライセンス | アクション |
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Eur J Neurosci_39_375-391.pdf (773.6 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-08-12 | |||||
| タイトル | ||||||
| タイトル | Neurobiology of pain, interoception and emotional response: lessons from nerve growth factor-dependent neurons | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | congenital insensitivity to pain with anhidrosis, hereditary sensory and autonomic neuropathy, NTRK1, polymodal receptor, TrkA | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Indo, Yasuhiro
× Indo, Yasuhiro |
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| 別言語の著者 |
犬童, 康弘
× 犬童, 康弘 |
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| 内容記述 | ||||||
| 内容記述 | Although nerve growth factor (NGF) is a well-known neurotrophic factor, it also acts as a mediator of pain, itch and inflammation. Congenital insensitivity to pain with anhidrosis (CIPA) is an autosomal recessive genetic disorder caused by loss-of-function mutations in NTRK1, the gene encoding a receptor tyrosine kinase for NGF, TrkA. Mutations in NTRK1 cause the selective loss of NGF-dependent neurons in otherwise intact systems. NGF-dependent primary afferents are thinly myelinated Aδ or unmyelinated C-fibers that are dependent on the NGF-TrkA system during development. In CIPA, the lack of pain and the presence of anhidrosis (inability to sweat) are due to the absence of both NGF-dependent primary afferents and sympathetic postganglionic neurons, respectively. These peripheral neurons form an interface between the nervous system and the 'body-proper' and play essential roles in the interoception and sympathetic regulation of various tissues or organs. Patients with CIPA also show mental retardation and characteristic behaviors and are probably neuron-deficient within the brain. However, the functions of NGF-dependent neurons in the brain are controversial, both in animal and in human studies. This review focuses on various brain regions that express TrkA mRNA, based on data from the Allen Human Brain Atlas, and discusses putative neuronal networks related to these brain regions in humans. A better understanding the distribution of NGF-dependent neurons in the brain will provide a framework for further studies to investigate pain, interoception and emotional responses. Furthermore, strategies targeting the molecular mechanisms through which the NGF-TrkA system functions may provide hope for the development of novel analgesics. | |||||
| 書誌情報 |
European Journal of Neuroscience 巻 39, 号 3, p. 375-391, 発行年 2014-02-04 |
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| ISSN | ||||||
| 収録物識別子 | 0953816X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1111/ejn.12448 | |||||
| 権利 | ||||||
| 権利情報 | © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 773581 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.7 | |||||
| 出版者 | ||||||
| 出版者 | John Wiley & Sons, Inc. | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://onlinelibrary.wiley.com/doi/10.1111/ejn.12448/abstract | |||||
| コメント | ||||||
| 【著者所属】熊本大学医学部附属病院小児科 | ||||||
| コメント | ||||||
| This is the peer reviewed version of the following article: [http://onlinelibrary.wiley.com/doi/10.1111/ejn.12448/abstract], which has been published in final form at [DOI: 10.1111/ejn.12448]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | ||||||
