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Lactic Acid Bacteria Convert Human Fibroblasts to Multipotent Cells
http://hdl.handle.net/2298/32922
http://hdl.handle.net/2298/3292225b829ee-08c8-4462-bdfa-b6aab9272b88
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PLOS ONE_7_12_e51866.pdf (2.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-09-02 | |||||
| タイトル | ||||||
| タイトル | Lactic Acid Bacteria Convert Human Fibroblasts to Multipotent Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
太田, 訓正
× 太田, 訓正× Kawano, Rie× Ito, Naofumi |
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| 別言語の著者 |
太田, 訓正
× 太田, 訓正× 河野, 利恵× 伊藤, 尚文 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The human gastrointestinal tract is colonized by a vast community of symbionts and commensals. Lactic acid bacteria (LAB) form a group of related, low-GC-content, gram-positive bacteria that are considered to offer a number of probiotic benefits to general health. While the role of LAB in gastrointestinal microecology has been the subject of extensive study, little is known about how commensal prokaryotic organisms directly influence eukaryotic cells. Here, we demonstrate the generation of multipotential cells from adult human dermal fibroblast cells by incorporating LAB. LAB-incorporated cell clusters are similar to embryoid bodies derived from embryonic stem cells and can differentiate into endodermal, mesodermal, and ectodermal cells in vivo and in vitro. LAB-incorporated cell clusters express a set of genes associated with multipotency, and microarray analysis indicates a remarkable increase of NANOG, a multipotency marker, and a notable decrease in HOX gene expression in LAB-incorporated cells. During the cell culture, the LAB-incorporated cell clusters stop cell division and start to express early senescence markers without cell death. Thus, LAB-incorporated cell clusters have potentially wide-ranging implications for cell generation, reprogramming, and cell-based therapy. | |||||
| 書誌情報 |
PLOS ONE 巻 7, 号 12, p. 1-10, 発行年 2012-12-26 |
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| ISSN | ||||||
| 収録物識別子 | 19326203 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1371/journal.pone.0051866 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 2484710 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | Public Library of Science | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051866 | |||||
| コメント | ||||||
| 値 | 【著者所属】熊本大学 大学院生命科学研究部 神経分化学 | |||||
