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Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses
http://hdl.handle.net/2298/32941
http://hdl.handle.net/2298/329417bc200f5-b3c8-41e5-8930-ef3da6d25b7d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Scientific Reports_4_4680.pdf (5.9 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2015-09-03 | |||||
| タイトル | ||||||
| タイトル | Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Khan, Shahzada
× Khan, Shahzada× Rahman, H. N. Ashiqur× 岡本, 竜哉× Matsunaga, Tetsuro× Fujiwara, Yukio× 澤, 智裕× Yoshitake, Jun× 小野, 克彦× Ahmed, Khandaker Ahtesham× Rahaman, Md. Mizanur× 小山, 耕太× 竹屋, 元裕× Ida, Tomoaki× Kawamura, Yoshiaki× 藤井, 重元× 赤池, 孝章 |
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| 別言語の著者 |
岡本, 竜哉
× 岡本, 竜哉× 松永, 哲郎× 藤原, 章雄× 澤, 智裕× 吉武, 淳× 小野, 克彦× 小山, 耕太× 竹屋, 元裕× 河村, 好章× 藤井, 重元× 赤池, 孝章 |
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| 内容記述 | ||||||
| 内容記述 | Helicobacter cinaedi is the most common enterohepatic Helicobacter species that causes bacteremia in humans, but its pathogenicity is unclear. Here, we investigated the possible association of H. cinaedi with atherosclerosis in vivo and in vitro. We found that H. cinaedi infection significantly enhanced atherosclerosis in hyperlipidaemic mice. Aortic root lesions in infected mice showed increased accumulation of neutrophils and F4/801^+ foam cells, which was due, at least partly, to bacteria-mediated increased expression of proinflammatory genes. Although infection was asymptomatic, detection of cytolethal distending toxin RNA of H. cinaedi indicated aorta infection. H. cinaedi infection altered expression of cholesterol receptors and transporters in cultured macrophages and caused foam cell formation. Also, infection induced differentiation of THP-1 monocytes. These data provide the first evidence of a pathogenic role of H. cinaedi in atherosclerosis in experimental models, thereby justifying additional investigations of the possible role of enterohepatic Helicobacter spp. in atherosclerosis and cardiovascular disease. | |||||
| 書誌情報 |
Scientific Reports 巻 4, 号 4680, p. 1-12, 発行年 2014-04-15 |
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| ISSN | ||||||
| 収録物識別子 | 20452322 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.1038/srep04680 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 5852508 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
| 出版者 | ||||||
| 出版者 | Nature Publishing Group | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.nature.com/articles/srep04680 | |||||
