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Human T-cell leukaemia virus type 1 : parasitism and pathogenesis
http://hdl.handle.net/2298/41364
http://hdl.handle.net/2298/41364b34fdaad-a99f-4b8e-a46a-80e56c9c5673
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Philpsophical_transactions_B_2017_20160272_full.pdf (608.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2019-01-15 | |||||
| タイトル | ||||||
| タイトル | Human T-cell leukaemia virus type 1 : parasitism and pathogenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | HTLV-1, Tax, HBZ | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Bangham, Charles R. M.
× Bangham, Charles R. M.× Matsuoka, Masao |
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| 別言語の著者 |
松岡, 雅雄
× 松岡, 雅雄 |
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| 内容記述 | ||||||
| 内容記述 | Human T-cell leukaemia virus type 1 (HTLV-1) causes not only adult T-cell leukaemia-lymphoma (ATL), but also inflammatory diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 transmits primarily through cell-to-cell contact, and generates abundant infected cells in the host in order to survive and transmit to a new host. The resulting high proviral load is closely associated with the development of ATL and inflammatory diseases. To increase the number of infected cells, HTLV-1 changes the immunophenotype of infected cells, induces proliferation and inhibits apoptosis through the cooperative actions of two viral genes, tax and HTLV-1 bZIP factor (HBZ). As a result, infected cells survive, proliferate and infiltrate into the tissues, which is critical for transmission of the virus. Thus, the strategy of this virus is indivisibly linked with its pathogenesis, providing a clue for prevention and treatment of HTLV-1-induced diseases. This article is part of the themed issue ‘Human oncogenic viruses’. |
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| 書誌情報 |
Philosophical Transactions of the Royal Society B : Biological Sciences 巻 372, 号 20160272, p. 1-10, 発行年 2017-09-12 |
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| ISSN | ||||||
| 収録物識別子 | 14712970 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | https://doi.org/10.1098/rstb.2016.0272 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 607955 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491 | |||||
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| 出版者 | The Royal Society | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | https://royalsocietypublishing.org/doi/10.1098/rstb.2016.0272 | |||||
