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Photochemical identification of the binding region for (S)-semotiadil on sodium channels: Comparison with that for (R)-semotiadil on skeletal muscle calcium channel
http://hdl.handle.net/2298/27922
http://hdl.handle.net/2298/27922dca590d1-9361-4b70-b571-d9faf32616a1
名前 / ファイル | ライセンス | アクション |
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COM-02-S62.pdf (229.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-06-04 | |||||
タイトル | ||||||
タイトル | Photochemical identification of the binding region for (S)-semotiadil on sodium channels: Comparison with that for (R)-semotiadil on skeletal muscle calcium channel | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Yoshikawa, Hiromi
× Yoshikawa, Hiromi× Shimizu, Eisuke× Kawahara, Kohichi× Kuniyasu, Akihiko× Shibano, Toshiro× 中山, 仁 |
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別言語の著者 |
吉川, 裕美
× 吉川, 裕美× 清水, 英介× 川原, 浩一× 國安, 明彦× 芝野, 俊郎× 中山, 仁 |
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内容記述 | ||||||
内容記述 | To clarify the recognition site of (S)-semotiadil in the Na+ channels, we employed photoaffinity labeling with (S)-[3H]-D51-4700, an azidophenyl derivative of (S)-semotiadil, to Na+ channel preparations from rat brains and porcine hearts, and the results were compared with those by (R)-enantiomer to skeletal muscle Ca2+ channel. Protease-digestion of the photolabeled Na+ channels followed by quantitative immunoprecipitation assay using a site-directed antibody, revealed that 10- and 13- kDa fargments of brain and cardiac Na+ channels, respectively, were located within the regions including IVS6. These regions are corresponding to the 8.3 kDa fragment photolabled by (R)-[3H]-D51- 4700 in the skeletal muscle Ca2+ channel. Interestingly, however, the photoincorporation of (S)-[3H]-D51-4700 into the Na+ channel was 2-3 times higher than that of (R)-isomer; and visa versa in the Ca2+ channels. |
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書誌情報 |
Heterocycles 巻 59, 号 2, p. 613-622, 発行年 2003 |
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ISSN | ||||||
収録物識別子 | 1881-0942 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
関連識別子 | 10.3987/COM-02-S62 | |||||
権利 | ||||||
権利情報 | © 2002 The Japan Institute of Heterocyclic Chemistry | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
229218 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
日本十進分類法 | ||||||
主題 | 430 | |||||
出版者 | ||||||
出版者 | The Japan Institute of Heterocyclic Chemistry | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.heterocycles.jp/newlibrary/libraries/abst/00997 |