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Halenaquinone inhibits RANKL-induced osteoclastogenesis
http://hdl.handle.net/2298/00043538
http://hdl.handle.net/2298/00043538ed524006-33d0-45f6-84d8-9ff6a61d0e5c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
0960-849v24_5315-5317 (1.5 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-10-26 | |||||
| タイトル | ||||||
| タイトル | Halenaquinone inhibits RANKL-induced osteoclastogenesis | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Halenaquinone, Osteoclastogenesis, Marine sponge, Petrosia alfiani | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukamoto, Sachiko
× Tsukamoto, Sachiko× Takeuchi, Tomoharu× Kawabata, Tetsuro× Kato, Hikaru× Yamakuma,Michiko× Matsuo, Kanae× El-Desoky, Ahmed H.× Losung, Fitje× Mangindaan, Remy E.P.× de Voogd, Nicole J.× Arata, Yoichiro× Yokosawa, Hideyoshi |
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| 抄録 | ||||||
| 内容記述 | Halenaquinone was isolated from the marine sponge Petrosia alfiani as an inhibitor of osteoclastogenic differentiation of murine RAW264 cells. It inhibited the RANKL (receptor activator of nuclear factor-κB ligand)-induced upregulation of TRAP (tartrate-resistant acid phosphatase) activity as well as the formation of multinuclear osteoclasts. In addition, halenaquinone substantially suppressed RANKL-induced IκB degradation and Akt phosphorylation. Thus, these results suggest that halenaquinone inhibits RANKL-induced osteoclastogenesis at least by suppressing the NF-κB and Akt signaling pathways. | |||||
| 書誌情報 |
en : Bioorganic & Medicinal Chemistry Letters 巻 24, 号 22, p. 5315-5317, 発行年 2014-11-15 |
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| ISSN | ||||||
| 収録物識別子 | 0960-894X | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1016/j.bmcl.2014.09.043 | |||||
| 権利 | ||||||
| 権利情報 | (C) 2020 This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 483.2 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499.3 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 言語 | en | |||||
