WEKO3
アイテム
Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats
http://hdl.handle.net/2298/15509
http://hdl.handle.net/2298/15509480ae565-c2c0-45df-8002-c47b53164b66
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PharmRes-MORISAKI_r.pdf (336.7 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-26 | |||||
| タイトル | ||||||
| タイトル | Regulation of renal organic ion transporters in cisplatin-induced acute kidney injury and uremia in rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | acute kidney injury, cisplatin, indoxyl sulfate, organic anion transporter, organic cation transporter | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Morisaki, Takafumi
× Morisaki, Takafumi× Matsuzaki, Takanobu× Yokoo, Koji× Kusumoto, Masahiro× Iwata, Kazufumi× 濱田, 哲暢× Saito, Hideyuki |
|||||
| 別言語の著者 |
森崎, 崇文
× 森崎, 崇文× 松崎, 尊信× 横尾, 浩司× 楠本, 将裕× 岩田, 一史× 濱田, 哲暢× 齋藤, 秀之 |
|||||
| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Purpose The purpose of this study was to examine the regulation of renal organic ion transporters in cisplatin-induced acute kidney injury (AKI) and its relation with indoxyl sulfate (IS), a uremic toxin. Methods The IS concentrations in the serum and kidney were monitored by high-performance liquid chromatography. Uptake of p-aminohippuric acid, estrone-3-sulfate and tetraethylammonium were examined using renal slices. Real-time PCR and immunoblotting were performed to examine the mRNA and protein expression of rOATs, rOCTs and rMATE1 in the kidney, respectively. Results The serum and renal IS levels were markedly elevated in cisplatin-treated rats. However, this effect was largely reversed by administration of AST-120, an oral charcoal adsorbent. The functions of renal basolateral organic anion and cation transporters were reduced in cisplatin-treated rats. The levels of mRNA and protein corresponding to rOAT1, rOAT3, rOCT2 and rMATE1, but not rOCT1, were depressed in the kidney of cisplatin-treated rats. Administration of AST-120 to cisplatin-treated rats partially restored the function and expression level of these transporters. Conclusions Cisplatin-induced AKI causes down-regulation of renal organic ion transporters accompanied by accumulation of serum and renal IS. IS could be involved in the mechanism of down-regulation of rOAT1, rOAT3 and rMATE1 under cisplatin-induced AKI. |
|||||
| 書誌情報 |
Pharmaceutical Research 巻 25, 号 11, p. 2526-2533, 発行年 2008-07-09 |
|||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s11095-008-9668-2 | |||||
| 権利 | ||||||
| 権利情報 | © Springer | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 07248741 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 336690 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.5 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.65 | |||||
| 出版者 | ||||||
| 出版者 | Springer Netherlands | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/t244462842j0v631/ | |||||
