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Relation of Bone Mineral Density to Vitamin D Receptor Gene Polymorphism and Lifestyle Factors in Japanese Female Workers Aged 22-44 Years: A Cross-Sectional Study
http://hdl.handle.net/2298/18178
http://hdl.handle.net/2298/1817830fa4481-3aa1-48e3-a463-d89014c2d230
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JNSV56_1_27-33.pdf (433.4 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-03-03 | |||||
| タイトル | ||||||
| タイトル | Relation of Bone Mineral Density to Vitamin D Receptor Gene Polymorphism and Lifestyle Factors in Japanese Female Workers Aged 22-44 Years: A Cross-Sectional Study | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題 | bone mineral density, gene polymorphism, lifestyle factors, vitamin D receptor | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Funakoshi, Yayoi
× Funakoshi, Yayoi× Omori, Hisamitsu× Katoh, Takahiko |
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| 別言語の著者 |
舩越, 弥生
× 舩越, 弥生× 大森, 久光× 加藤, 貴彦 |
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| 内容記述 | ||||||
| 内容記述 | Bone mineral density (BMD) reflects both genetic and lifestyle factors. The aim of this cross-sectional study was to investigate the influence of vitamin D receptor (VDR) gene polymorphism and lifestyle factors on BMD in premenopausal female workers. The subjects were 162 premenopausal female employees aged 22-44 y who worked at a large-scale integrated manufacturing facility in Japan. BMD was measured at the nondominant radius by dual energy X-ray absorptiometry. Lifestyle information was obtained by a questionnaire at the same time and genomic DNA was isolated from peripheral leukocytes. BMD was positively correlated with age, weight, and body mass index (BMI). The genotype frequencies of VDR gene polymorphism detected by TaqI analysis were 77.2, 22.8, and 0.0% for TT, Tt, and tt, respectively. Analysis of covariance with adjustment for age and BMI showed that the mean BMD was significantly lower in subjects with the Tt genotype than in those with the TT genotype. Subjects who drank alcohol also showed a significantly lower BMD if they had the Tt genotype than if they had the TT genotype. According to multiple linear regression analysis, the independent determinants of BMD were age, BMI, and VDR gene polymorphism. Our data show that BMD is negatively correlated with the Tt genotype of the VDR gene, but positively correlated with age and BMI. These findings suggest that analysis of VDR gene polymorphism may be useful for identifying individuals who are susceptible to osteoporosis so that early preventive measures can be provided. | |||||
| 書誌情報 |
Journal of Nutritional Science and Vitaminology 巻 56, 号 1, p. 27-33, 発行年 2010-02-01 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00703822 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 関連識別子 | 10.3177/jnsv.56.27 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 03014800 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 433390 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.4 | |||||
| 出版者 | ||||||
| 出版者 | 社団法人日本栄養・食糧学会 | |||||
| 出版者 | ||||||
| 出版者 | 日本ビタミン学会 | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.jstage.jst.go.jp/article/jnsv/56/1/56_27/_article/-char/ja/ | |||||
