WEKO3
アイテム
Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats
http://hdl.handle.net/2298/18978
http://hdl.handle.net/2298/189780d394447-4510-4772-9cfa-a869e8571636
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
リバイス-r.pdf (3.2 MB)
|
|
|
|
NS_170_1_298-307.pdf (135.1 kB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2011-05-23 | |||||
| タイトル | ||||||
| タイトル | Quinolinate induces selective loss of melanin-concentrating hormone neurons, rather than orexin neurons, in the hypothalamus of mice and young rats | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | excitotoxicity, hypocretin, narcolepsy, quinolinic acid | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Obukuro, Kanae
× Obukuro, Kanae× Takigawa, Moeko× Hisatsune, Akinori× Isohama, Yoichiro× 香月, 博志 |
|||||
| 別言語の著者 |
小袋, 加奈絵
× 小袋, 加奈絵× 瀧川, 萌子× 久恒, 昭哲× 礒濱, 洋一郎× 香月, 博志 |
|||||
| 内容記述 | ||||||
| 内容記述 | Orexins are neuropeptides produced in the lateral hypothalamus and implicated in regulation of sleep-wake cycle. Selective loss of orexin neurons is found in the brain of patients with narcolepsy, but the mechanisms of this pathological change are unclear. A previous study showed that excessive stimulation of N-methyl-D-aspartate (NMDA) receptors by quinolinic acid (QA) caused selective loss of orexin neurons in rat hypothalamic slice culture. Here we examined QA toxicity on orexin neurons and melanin-concentrating hormone (MCH) neurons in vivo. Contrary to the expectation, injection of QA (60 and 120 nmol) into the lateral hypothalamus of male C57BL/6 mice caused selective loss of MCH neurons rather than orexin neurons, and this toxicity of QA was attenuated by MK-801, an NMDA receptor antagonist. Selective loss of MCH neurons with preserved orexin neurons was observed even when GABAA receptor antagonists such as bicuculline and picrotoxin were injected with QA. A significant decrease in the number of orexin neurons was induced when QA injection was performed in the dark phase of diurnal cycle, but the degree of the decrease was still lower than that in the number of MCH neurons. Finally, QA (60 nmol) induced selective loss of MCH neurons also in young rats at 3 - 4 weeks of age. These results do not support the hypothesis that acute excitotoxicity mediated by NMDA receptors is responsible for the pathogenesis of narcolepsy. | |||||
| 書誌情報 |
Neuroscience 巻 170, 号 1, p. 298-307, 発行年 2010-09-29 |
|||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1016/j.neuroscience.2010.06.081 | |||||
| 権利 | ||||||
| 権利情報 | © 2010 IBRO. Published by Elsevier Ltd | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 03064522 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 135103 bytes | ||||||
| 形態 | ||||||
| 3225402 bytes | ||||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.17 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 491.5 | |||||
| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
| 資源タイプ・DCMI | ||||||
| text | ||||||
| 資源タイプ・ローカル表示コード | ||||||
| 01 | ||||||
| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.scopus.com/record/display.url?eid=2-s2.0-77955920655&origin=resultslist&sort=plf-f&src=s&st1=QUINOLINATE+INDUCES+SELECTIVE+LOSS&sid=f-qhVPJ2u2Lk21TXA-UeNmo%3a90&sot=b&sdt=b&sl=49&s=TITLE-ABS-KEY%28QUINOLINATE+INDUCES+SELECTIVE+LOSS%29&relpos=0&relpos=0&searchTerm=TITLE-ABS-KEY%28QUINOLINATE%20INDUCES%20SELECTIVE%20LOSS%29 | |||||
