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Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy
http://hdl.handle.net/2298/19344
http://hdl.handle.net/2298/19344ddd00112-3b20-470b-9595-91928beb9ce6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
PM_76_11_1064-1074.pdf (1.1 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-06-06 | |||||
| タイトル | ||||||
| タイトル | Inhibition of the ubiquitin-proteasome system by natural products for cancer therapy | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | natural products, ubiquitin, proteasome, cancer therapy, drug discovery, targeted therapy | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
Tsukamoto, Sachiko
× Tsukamoto, Sachiko× Yokosawa, Hideyoshi |
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| 抄録 | ||||||
| 内容記述 | The ubiquitin-proteasome system plays a critical role in selective protein degradation and regulates almost all cellular events such as cell cycle progression, signal transduction, cell death, immune responses, metabolism, protein quality control, development, and neuronal function. The recent approval of bortezomib, a synthetic proteasome inhibitor, for the treatment of relapsed multiple myeloma has opened the way to the discovery of drugs targeting the proteasome and ubiquitinating and deubiquitinating enzymes as well as the delivery system. To date, various synthetic and natural products have been reported to inhibit the components of the ubiquitin-proteasome system. Here, we review natural products targeting the ubiquitin-proteasome system as well as synthetic compounds with potent inhibitory effects. | |||||
| 書誌情報 |
en : Planta Medica 巻 76, 号 11, p. 1064-1074, 発行年 2010-02-25 |
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| ISSN | ||||||
| 収録物識別子 | 0032-0943 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | https://doi.org/10.1055/s-0029-1240901 | |||||
| 権利 | ||||||
| 権利情報 | (C) Georg Thieme Verlag KG Stuttgart ・ New York | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 499 | |||||
| 出版者 | ||||||
| 出版者 | Georg Thieme Verlag | |||||
| 言語 | en | |||||
