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Histological liver injury and surgical outcome after FOLFOX followed by a hepatectomy for colorectal liver metastases in Japanese patients
http://hdl.handle.net/2298/19861
http://hdl.handle.net/2298/198617d4e0a9f-5a91-4181-b5ef-4357f9e9b72d
| 名前 / ファイル | ライセンス | アクション |
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IJCO_15_3_Tables.pdf (112.0 kB)
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IJCO_15_3_263.pdf (98.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2011-06-27 | |||||
| タイトル | ||||||
| タイトル | Histological liver injury and surgical outcome after FOLFOX followed by a hepatectomy for colorectal liver metastases in Japanese patients | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題 | Colorectal liver metastases, Fluorouracil and leucovorin (FOLFOX), Hepatic resection, Oxaliplatin, Postoperative morbidity, Sinusoidal dilatation | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| 著者 |
小森, 宏之
× 小森, 宏之× Beppu, Toru× 馬場, 祥史× Horino, Kei× Imsung, Choi× 増田, 稔郎× 林, 洋光× Okabe, Hirohisa× Ootao, Ryuu× 渡邊, 雅之× Takamori, Hiroshi× Iyama, Kenichi× Baba, Hideo |
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| 別言語の著者 |
小森, 宏之
× 小森, 宏之× 別府, 透× 馬場, 祥史× 堀野, 敬× 増田, 稔郎× 林, 洋光× 岡部, 弘尚× 太田尾, 龍× 渡邊, 雅之× 高森, 啓史× 猪山, 賢一× 馬場, 秀夫 |
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| 内容記述 | ||||||
| 内容記述 | Background This study was performed to clarify the influence of preoperative chemotherapy on liver function and the correlation between histological hepatic injury and the postoperative outcome in patients with colorectal liver metastases who underwent a hepatic resection. Methods Twenty-seven patients who underwent a hepatic resection for colorectal liver metastases were included. Fifteen patients with initially unresectable colorectal liver metastases who were able to undergo a tumor resection after FOLFOX (oxaliplatin plus fluorouracil and leucovorin, with a mean number of 7.7 cycles) were compared to 12 patients who underwent a hepatectomy with no preoperative chemotherapy. The postoperative mortality, morbidity, changes in liver function tests, and pathology of the resected liver were examined. Results Preoperative FOLFOX therapy was significantly associated with the macroscopic appearance of oxaliplatinassociated blue liver (p = 0.02), and a tendency toward sinusoidal dilatation (33.3% in the FOLFOX group versus 8.3% in the no-chemotherapy group, p = 0.056). Preoperative liver function tests showed that the albumin and indocyanine green retention rate at 15 min (ICG-R15) test values were significantly worse after FOLFOX therapy; however, intraoperative events, postoperative liver function test values, and morbidity rates were similar in the two groups. There was no postoperative mortality in any of the patients. Conclusions Although preoperative FOLFOX administration in patients with colorectal liver metastases caused macroscopic blue liver, microscopic sinusoidal dilatationin the liver parenchyma, and a significant decrease in liver function, there was no increase in the morbidity and mortality rates, in comparison to findings in patients without preoperative chemotherapy. | |||||
| 書誌情報 |
International Journal of Clinical Oncology 巻 15, 号 3, p. 263-270, 発行年 2010-06 |
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| PubMed番号 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 20238233 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1007/s10147-010-0046-9 | |||||
| 権利 | ||||||
| 権利情報 | ©Japan Society of Clinical Oncology 2010 | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 13419625 | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
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| 98194 bytes | ||||||
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| 112004 bytes | ||||||
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| 出版タイプ | AM | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.4 | |||||
| 出版者 | ||||||
| 出版者 | Japan Society of Clinical Oncology | |||||
| 出版者 | ||||||
| 出版者 | Springer | |||||
| 別言語の出版者 | ||||||
| 一般社団法人日本癌治療学会 | ||||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
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| 雑誌掲載論文 | ||||||
| 資源タイプ・NII | ||||||
| Journal Article | ||||||
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| URL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | http://www.springerlink.com/content/pnr82711x3652312/ | |||||
| コメント | ||||||
| The original publication is available at www.springerlink.com | ||||||
